Desktop micromilled microfluidics
Desktop micromilled microfluidics
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DOI：
10.1007/s10404-018-2048-2
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发表时间：
2018-03-01
影响因子：
2.8
通讯作者：
Densmore, Douglas
中科院分区：
文献类型：
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作者：
Lashkaripour, Ali;Silva, Ryan;Densmore, Douglas
微铣削是一种经过验证的微流体装置原型制作方法；然而，高昂的管理成本、庞大的机器占地面积、深奥的软件堆栈和非标准的设备粘合协议可能会阻碍微铣削在更大的微流体社区中的广泛采用。这项研究利用了免费的设备设计软件链，并用它来探索新型廉价的台式微磨机在用聚碳酸酯制造微流体设备时的适用性。我们提出了一个用于分层微铣削的空间精度和表面质量的分析框架。利用这一点，我们得出结论，在精度和最小特征尺寸方面，直接在基材上铣削几何形状有利于用基材制造模具。此外，我们提出了一个通用程序，用于根据推荐的负载百分比计算任何亚毫米立铣刀的进给率和主轴速度。我们还确定步距是决定表面质量的主要参数，而不是主轴速度和进给率，这表明低成本铣床能够提供高质量的表面光洁度。最终，我们通过演示速率和尺寸控制的微流体液滴生成，阐明了低成本微磨机和具有成本效益的组装方法在微流体领域的适用性。
Micromilling is a proven method for prototyping microfluidic devices; however, high overhead costs, large machine footprints, an esoteric software stack, and nonstandard device bonding protocols may be hampering the widespread adoption of micromilling in the greater microfluidics community. This research exploits a free design-to-device software chain and uses it to explore the applicability of a new class of inexpensive, desktop micromills for fabricating microfluidic devices out of polycarbonate. We present an analysis framework for stratifying micromill's spatial accuracy and surface quality. Utilizing this we concluded milling geometries directly on the substrate is advantageous to making molds out of the substrate, in terms of accuracy and minimum feature size. Moreover, we proposed a general procedure to calculate feedrate and spindle-speed for any sub-millimeter endmill based on a recommended load percentage. We also established stepover is the major parameter in determining the surface quality rather than spindle-speed and feedrate, showing low-cost mills are able to deliver high-quality surface finishes. Ultimately, we clarified the suitability of low-cost micromills and a cost-efficient assembly method in the field of microfluidics by demonstrating rate- and size-controlled microfluidic droplet generation.