Cellular substrates of p34-c-dc2 and its companion cyclin-dependent kinases
Cellular substrates of p34-c-dc2 and its companion cyclin-dependent kinases
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DOI：
10.1016/0962-8924(93)90011-o
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发表时间：
1993-01-01
影响因子：
19
通讯作者：
Nigg, Erich A.
中科院分区：
文献类型：
--
作者：
Nigg, Erich A.
细胞周期蛋白依赖性激酶 (cdks) 是驱动所有真核生物细胞增殖周期的引擎的关键组成部分。这些激酶与 p34cdc2 相关，并与属于细胞周期蛋白家族的调节亚基相关。为了了解 cdks 如何促进细胞周期进程，确定其生理底物并确定磷酸化如何影响这些底物的功能非常重要。本文讨论了最近的进展以及与寻找 cdk 底物相关的一些问题。
Cyclin-dependent kinase (cdks) are key components of the engine that drives the cell proliferation cycle in all eukaryotes. These kinases are related to p34cdc2and associate with regulatory subunits belonging to the cyclin family. To understand how cdks promote cell cycle progression, it will be important to identify their physiological substrates and to determine how phosphorylation influences the functions of these substrates. This article discusses recent progress as well as some of the problems related to the quest for cdk substrates.