Regional blood flow effects of ANP in conscious dogs: preferential gastrointestinal vasoconstriction.
Regional blood flow effects of ANP in conscious dogs: preferential gastrointestinal vasoconstriction.
复制标题
ANP 对清醒狗的局部血流影响：优先胃肠道血管收缩。
DOI：
--
复制
发表时间：
1991
影响因子：
--
通讯作者：
J. Smolich
中科院分区：
文献类型：
--
作者：
R. Woods;J. Smolich
我们用放射性微球研究了6只清醒犬对人心钠素(α-hANP)的整体和局部血流反应。在存在和不存在自主神经反射的情况下，用神经节阻滞剂喷妥拉明测定每只犬对注射75 ng·kg~(-1)·min~(-1)α-hANP的血流动力学反应。当自主神经反射被阻断时，α-hANP导致胃肠道(GI)血管传导性显著降低(35%)，但对大脑、肾脏、肝脏、骨骼肌或皮肤没有显著影响。在自主神经阻断后，这种由α-hANP引起的GI电导下降对总外周电导(TPC)下降24%的贡献超过40%。心肌血管传导性的下降，尤其是在左心室，对TPC的下降又贡献了40%。当自主神经反射完整时，α-hANP引起胃肠道血管收缩(血管电导下降29%)，对心肌血管电导无明显影响，但显著增加脾血管电导。除了这些全身反应外，注射α-hANP还显著降低了肺血管传导性，与自主神经反射活动或肺动脉压变化无关。因此，我们在清醒的狗身上的结果表明，α-hANP引起全身血管收缩，最明显的是在胃肠道区域。
We studied total and regional blood flow responses to human atrial natriuretic peptide (alpha-hANP) using radioactive microspheres in six conscious dogs. Hemodynamic responses to infusions of alpha-hANP at 75 ng.kg-1.min-1 were determined in each dog in the presence and absence of autonomic reflexes using the ganglion blocking agent pentolinium. When autonomic reflexes were blocked, alpha-hANP caused a substantial reduction in gastrointestinal (GI) vascular conductance (35%) but had no significant effects in brain, kidneys, liver, skeletal muscle, or skin. This alpha-hANP-induced fall in GI conductance contributed more than 40% to the fall in total peripheral conductance (TPC) of 24% occurring after autonomic blockade. A fall in myocardial vascular conductance, most prominent in the left ventricle, contributed a further 40% to the fall in TPC. When autonomic reflexes were intact, alpha-hANP caused vasoconstriction in the GI region (29% fall in vascular conductance), had no significant effects on myocardial vascular conductance but significantly increased splenic vascular conductance. In addition to these systemic responses, alpha-hANP infusion also significantly reduced pulmonary vascular conductance, independent of autonomic reflex activity or changes in pulmonary artery pressure. Thus our results in conscious dogs demonstrate that alpha-hANP causes a systemic vasoconstriction, most pronounced in the GI region.