Development and testing of a single frequency terahertz imaging system for breast cancer detection.
Development and testing of a single frequency terahertz imaging system for breast cancer detection.
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DOI：
10.1109/jbhi.2013.2267351
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发表时间：
2013-07
影响因子：
7.7
通讯作者：
Karellas A
中科院分区：
文献类型：
--
作者：
St Peter B;Yngvesson S;Siqueira P;Kelly P;Khan A;Glick S;Karellas A
使用单频太赫兹辐射评估在乳房保护手术（BCS）中切除的人类乳房标本中辨别恶性与良性组织的能力。采用气体激光源和机械扫描的方式获得了反射模式下样品的太赫兹（THz）图像。图像与相同标本的光学组织学显微照片相关，使用受试者工作特征（ROC）分析发现六个样本中有五个样本的平均分辨力为73%。系统的设计和表征进行了详细讨论。初步结果令人鼓舞，但需要进一步开发该技术和临床评价，以评估其在临床环境中的可行性。
The ability to discern malignant from benign tissue in excised human breast specimens in Breast Conservation Surgery (BCS) was evaluated using single frequency terahertz radiation. Terahertz (THz) images of the specimens in reflection mode were obtained by employing a gas laser source and mechanical scanning. The images were correlated with optical histological micrographs of the same specimens, and a mean discrimination of 73% was found for five out of six samples using Receiver Operating Characteristic (ROC) analysis. The system design and characterization is discussed in detail. The initial results are encouraging but further development of the technology and clinical evaluation is needed to evaluate its feasibility in the clinical environment.