Role of central vasopressin in cardiovascular regulation.
Role of central vasopressin in cardiovascular regulation.
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中枢加压素在心血管调节中的作用。
DOI：
10.1097/00005344-198600087-00015
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发表时间：
1986
影响因子：
3
通讯作者：
Berecek,KH
中科院分区：
文献类型：
--
作者：
Berecek,KH
利用脑室内加压素给药、特定脑核团微量注射加压素、电刺激和特定核团消融等技术，我们发现加压素通过对中枢神经结构的作用，通过增加交感神经流出增加平均动脉压和心率，醋酸脱氧皮质酮（DOCA）-盐性高血压大鼠对加压素的中枢作用表现出增加的敏感性和反应性。此外，我们发现加压素心血管效应的一个重要中心靶区是脑桥蓝斑核。蓝斑消融显著减弱血管加压素的心血管效应以及DOCA盐高血压的发展。总之，我们的研究结果表明，加压素，蓝斑，交感神经系统在正常的心血管调节以及DOCA盐高血压的发病机制之间的联系。我们的研究支持加压素通过作用于中枢神经靶区（如控制交感神经流出的蓝斑）来改变交感神经驱动的假设。我们的数据进一步表明，加压素可能参与DOCA-盐高血压的发病机制，诱导刺激交感神经系统在该模型中的蓝斑区域。
Using techniques of intracerebroventricular administration of vasopressin, microinjection of vasopressin into specific brain nuclei, electrical stimulation, and ablation of specific nuclei, we found that vasopressin, through an effect on central neural structures, increases mean arterial pressure and heart rate via an increase in sympathetic outflow and that deoxycorticosterone acetate (DOCA)-salt hypertensive rats show increased sensitivity and responsiveness to the central effects of vasopressin. Furthermore, we found that an important central target area for the cardiovascular effects of vasopressin is the pontine nucleus locus coeruleus. Ablation of the locus coeruleus markedly attenuates the cardiovascular effects of vasopressin as well as the development of DOCA-salt hypertension. Taken together, our results suggest a link between vasopressin, the locus coeruleus, and the sympathetic nervous system in normal cardiovascular regulation as well as in the pathogenesis of DOCA-salt hypertension. Our studies support the hypothesis that vasopressin modifies sympathetic drive through an action on central neural target areas, such as the locus coeruleus controlling sympathetic outflow. Our data further suggests that vasopressin may participate in the pathogenesis of DOCA-salt hypertension by inducing stimulation of the sympathetic nervous system at the region of the locus coeruleus in this model.