Thromboxane inhibition reduces an early stage of chronic hypoxia-induced pulmonary hypertension in piglets.
Thromboxane inhibition reduces an early stage of chronic hypoxia-induced pulmonary hypertension in piglets.
复制标题
血栓素抑制可减少仔猪慢性缺氧引起的肺动脉高压的早期阶段。
DOI：
10.1152/japplphysiol.01337.2004
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
Kaplowitz,MarkR
中科院分区：
文献类型：
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作者：
Fike,CandiceD;Zhang,Yongmei;Kaplowitz,MarkR
肺血管收缩剂血栓素可能导致肺动脉高压的发生。我们的目的是确定一种联合血栓素合成酶抑制剂-受体拮抗剂terbogrel是否能预防暴露于缺氧3天的新生仔猪肺动脉高压和异常肺动脉反应的发生。仔猪在室内空气（对照组）或11%氧气（低氧）中维持3天。部分缺氧仔猪给予特博格雷（10 mg/kg）。测量麻醉动物肺动脉压、肺楔压和心输出量。采用空心动脉技术测量对乙酰胆碱的反应。特博格雷治疗的缺氧仔猪肺血管阻力几乎是未治疗的一半，但仍高于对照组。特博格雷治疗的缺氧仔猪的预缩肺动脉对乙酰胆碱的扩张大于未治疗的缺氧仔猪，但两组缺氧仔猪的肺动脉扩张均小于对照组。特博格雷可能改善新生儿肺动脉功能障碍和减轻慢性缺氧引起的肺动脉高压的发展。
The pulmonary vasoconstrictor, thromboxane, may contribute to the development of pulmonary hypertension. Our objective was to determine whether a combined thromboxane synthase inhibitor-receptor antagonist, terbogrel, prevents pulmonary hypertension and the development of aberrant pulmonary arterial responses in newborn piglets exposed to 3 days of hypoxia. Piglets were maintained in room air (control) or 11% O2(hypoxic) for 3 days. Some hypoxic piglets received terbogrel (10 mg/kg po bid). Pulmonary arterial pressure, pulmonary wedge pressure, and cardiac output were measured in anesthetized animals. A cannulated artery technique was used to measure responses to acetylcholine. Pulmonary vascular resistance for terbogrel-treated hypoxic piglets was almost one-half the value of untreated hypoxic piglets but remained greater than values for control piglets. Dilation to acetylcholine in preconstricted pulmonary arteries was greater for terbogrel-treated hypoxic than for untreated hypoxic piglets, but it was less for pulmonary arteries from both groups of hypoxic piglets than for control piglets. Terbogrel may ameliorate pulmonary artery dysfunction and attenuate the development of chronic hypoxia-induced pulmonary hypertension in newborns.