Basic fibroblast growth factor restores endothelium-dependent responses after balloon injury of rabbit arteries
Basic fibroblast growth factor restores endothelium-dependent responses after balloon injury of rabbit arteries
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DOI：
10.1161/01.cir.93.1.18
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发表时间：
1996-01-01
期刊：
影响因子：
37.8
通讯作者：
Bertrand, ME
中科院分区：
文献类型：
--
作者：
Meurice, T;Bauters, C;Bertrand, ME
Background After experimental angioplasty, partial or complete reendothelialization of the denuded surface occurs; the function of the regenerated endothelium has, however, been shown to be abnormal. Basic fibroblast growth factor (bFGF) is mitogenic for endothelial cells in vitro and in vivo. We investigated whether chronic administration of bFGF in a rabbit model of balloon denudation might not only improve endothelial regrowth but also restore normal physiological responses to endothelium-dependent agonists.Methods and Results Thirty-nine New Zealand White rabbits underwent balloon denudation of the right iliac artery. Twenty rabbits received intravenous administration of bFGF (2.5 mu g twice a week for 2 weeks). Nineteen rabbits receiving saline injections served as controls. Animals were killed on day 28 for assessment of reendothelialization and neointimal thickening and for analysis of in vitro vasoreactivity. Animals in the bFGF group had a significantly (P
