Ovarian cancer risk and common variation in the sex hormone-binding globulin gene: a population-based case-control study
Ovarian cancer risk and common variation in the sex hormone-binding globulin gene: a population-based case-control study
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DOI：
10.1186/1471-2407-7-60
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发表时间：
2007-04-05
期刊：
影响因子：
3.8
通讯作者：
Chanock, Stephen J.
中科院分区：
文献类型：
--
作者：
Garcia-Closas, Montserrat;Brinton, Louise A.;Chanock, Stephen J.
背景资料：性激素结合球蛋白（SHBG）是一种载体蛋白，调节血清性类固醇激素的生物利用度，可能与卵巢癌有关。我们评估是否共同的遗传变异SHBG和它的3'邻居ATP 1B 2，在连锁不平衡，与上皮性卵巢cancer.Methods的风险：研究人群包括264名妇女卵巢癌和625名对照参与人口为基础的病例对照研究在波兰。结果：SHBG D356 N（rs6259）和-67 G> A 5' UTR（rs 1799941）等5个SNPs与卵巢癌风险无显著相关性。然而，我们的数据是一致的卵巢癌的风险降低与这两个SNP的变异等位基因，这已经与增加循环水平的SHBG.Conclusion：这些数据不支持SHBG和卵巢癌的风险之间的共同遗传变异的实质性关联。
Background: The sex hormone-binding globulin ( SHBG) is a carrier protein that modulates the bio-availability of serum sex steroid hormones, which may be involved in ovarian cancer. We evaluated whether common genetic variation in SHBG and its 3' neighbor ATP1B2, in linkage disequilibrium, is associated with the risk of epithelial ovarian cancer.Methods: The study population included 264 women with ovarian carcinoma and 625 controls participating in a population-based case-control study in Poland. Five common single nucleotide polymorphisms ( SNPs) in SHGB and five in ATP1B2 were selected to capture most common variation in this region.Results: None of the SNPs evaluated was significantly associated with ovarian cancer risk, including the putative functional SNPs SHBG D356N (rs6259) and - 67G > A 5' UTR (rs1799941). However, our data were consistent with a decreased ovarian cancer risk associated with the variant alleles for these two SNPs, which have been previously associated with increased circulating levels of SHBG.Conclusion: These data do not support a substantial association between common genetic variation in SHBG and ovarian cancer risk.