High prevalence of SARS-CoV-2 and influenza A virus (H1N1) coinfection in dead patients in Northeastern Iran
High prevalence of SARS-CoV-2 and influenza A virus (H1N1) coinfection in dead patients in Northeastern Iran
复制标题
DOI：
10.1002/jmv.26364
复制
发表时间：
2020-08-13
影响因子：
12.7
通讯作者：
Azimian, Amir
中科院分区：
文献类型：
--
作者：
Hashemi, Seyed A.;Safamanesh, Saghar;Azimian, Amir
在2019年的最后几个月，中国武汉爆发了致命的呼吸道疾病，并迅速蔓延到世界其他地区。它被命名为COVID-19，迄今为止，全球报告了数千例感染和死亡病例。这种疾病与广泛的症状有关，这使得准确诊断变得困难。在2003年的严重急性呼吸综合征（SARS）大流行期间，研究人员发现，发烧、咳嗽或喉咙痛的患者有5%的流感病毒阳性率。这一发现使我们认为，我们的患者中广泛的症状和相对较高的死亡率可能是由于与其他病毒的合并感染。因此，我们评估了严重急性呼吸综合征冠状病毒2（SARS-CoV-2）与其他呼吸道病毒在呼罗珊北部死亡患者中的合并感染。我们使用聚合酶链反应（PCR）和逆转录PCR检测，评估了105例SARS-CoV-2阳性死亡患者中是否存在流感A/B病毒、人偏肺病毒、博卡病毒、腺病毒、呼吸道合胞病毒（RSV）和副流感病毒。在SARS-CoV-2阳性死亡病例中，我们发现流感病毒合并感染占22.3%，RSV和博卡病毒合并感染占9.7%，副流感病毒合并感染占3.9%，人偏肺病毒合并感染占2.9%，最后腺病毒合并感染占1.9%。我们的研究结果强调了与甲型流感病毒合并感染的高患病率和儿童中与人偏肺病毒合并感染的垄断。
In the last months of 2019, an outbreak of fatal respiratory disease started in Wuhan, China, and quickly spread to other parts of the world. It was named COVID-19, and to date, thousands of cases of infection and death are reported worldwide. This disease is associated with a wide range of symptoms, which makes accurate diagnosis of it difficult. During previous severe acute respiratory syndrome (SARS) pandemic in 2003, researchers found that the patients with fever, cough, or sore throat had a 5% influenza virus-positive rate. This finding made us think that the wide range of symptoms and also relatively high prevalence of death in our patients may be due to the coinfection with other viruses. Thus, we evaluated the coinfection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with other respiratory viruses in dead patients in North Khorasan. We evaluated the presence of influenza A/B virus, human metapneumovirus, bocavirus, adenovirus, respiratory syncytial virus (RSV), and parainfluenza viruses in 105 SARS-CoV-2 positive dead patients, using polymerase chain reaction (PCR) and reverse transcription PCR tests. We found coinfection with influenza virus in 22.3%, RSV, and bocavirus in 9.7%, parainfluenza viruses in 3.9%, human metapneumovirus in 2.9%, and finally adenovirus in 1.9% of SARS-CoV-2 positive dead cases. Our findings highlight a high prevalence of coinfection with influenza A virus and the monopoly of coinfection with Human metapneumovirus in children.