Signaling pathways in biliary epithelial cells
Signaling pathways in biliary epithelial cells
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DOI：
10.1007/3-540-27194-5_2
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发表时间：
2005-01-01
期刊：
影响因子：
--
通讯作者：
Nathanson, MH
中科院分区：
文献类型：
--
作者：
Leite, MF;Nathanson, MH
胆管上皮细胞或胆管细胞排列在胆管树的管腔中。与肝细胞一样，胆管细胞是一种极化上皮，其结构特征包括明确的顶膜域和基底外侧膜域。胆管细胞约占肝脏质量的 5%，通过一系列分泌和重吸收事件改变初级小管胆汁，在胆汁形成中发挥重要作用。这些事件受到肽激素、核苷酸、胆汁盐、生长因子、细胞因子和神经递质的调节，这些神经递质结合并刺激特定的顶端或基底外侧表面膜受体，进而启动调节细胞功能的细胞内信号转导途径。除了在胆管修饰中的作用外，胆管细胞还参与外源物质的解毒。
Biliary epithelial cells, or cholangiocytes, line the lumen of the biliary tree. Like hepatocytes, cholangiocytes are a polarized epithelium with structural features that include well‐defined apical and basolateral membrane domains. Cholangiocytes constitute approximately 5% of the mass of the liver and play an important role in the formation of bile by altering primary canalicular bile through a series of secretory and reabsorptive events. These events are regulated by peptide hormones, nucleotides, bile salts, growth factors, cytokines, and neurotransmitters that bind to and stimulate specific apical or basolateral surface membrane receptors, which in turn initiate intracellular signal transduction pathways that regulate cell function. In addition to their role in the modification of ductal bile, cholangiocytes participate in the detoxification of xenobiotics.