ON THE LOSS OF URICOLYTIC ACTIVITY DURING PRIMATE EVOLUTION .1. SILENCING OF URATE OXIDASE IN A HOMINOID ANCESTOR
ON THE LOSS OF URICOLYTIC ACTIVITY DURING PRIMATE EVOLUTION .1. SILENCING OF URATE OXIDASE IN A HOMINOID ANCESTOR
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DOI：
10.1016/0305-0491(85)90381-5
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发表时间：
1985-01-01
影响因子：
2.2
通讯作者：
MAYLE, JE
中科院分区：
文献类型：
--
作者：
FRIEDMAN, TB;POLANCO, GE;MAYLE, JE
尿酸氧化酶活性在来自长颈鹿、猩猩、黑猩猩、大猩猩和人类的肝匀浆中未检测到。来自旧世界猴的五个属和新世界猴的两个属的肝匀浆具有容易检测的尿酸氧化酶活性水平。没有证据表明在类人猿尿酸氧化酶活性丧失过程中存在可检测的中间步骤。来自旧世界和新世界猴子的尿酸氧化酶活性是稳定的，这一简单的观察证伪了一个长期存在的神话。尿酸氧化酶活性沉默的祖先的五个生活属的人科动物后，分歧从旧世界的猴子。
Urate oxidase activity is not detectable in liver homogenates from the gibbon, orangutan, chimpanzee, gorilla and human. Liver homogenates from five genera of Old World and two genera of New World monkeys have easily detectable levels of urate oxidase activity. There is no evidence for extant detectable intermediate steps in the loss of urate oxidase activity in the hominoids. Urate oxidase activity from Old World and New World monkeys is stable, a simple observation which falsifies a long-standing myth. Urate oxidase activity was silenced in an ancestor to the five living genera of hominoids after divergence from the Old World monkeys.