Vibration-induced hyperresponsiveness of arterial smooth muscle to noradrenaline with special reference to Raynaud's phenomenon in vibration disease.
Vibration-induced hyperresponsiveness of arterial smooth muscle to noradrenaline with special reference to Raynaud's phenomenon in vibration disease.
复制标题
振动引起的动脉平滑肌对去甲肾上腺素的高反应性，特别是振动疾病中的雷诺现象。
DOI：
10.1093/cvr/12.12.758
复制
发表时间：
1978
影响因子：
10.8
通讯作者：
M. Sakaguchi
中科院分区：
文献类型：
--
作者：
T. Azuma;T. Ohhashi;M. Sakaguchi
研究了体外和体内振动刺激对狗和大鼠离体股动脉去甲肾上腺素剂量反应关系的影响。施加刺激后，这些动脉的反应性增强。过度反应的程度取决于刺激的频率、幅度和持续时间。根据实验结果，为振动疾病中的雷诺现象提供了可能的解释。
Effects of in vitro and in vivo vibratory stimulations were studied on dose-response relationships of noradrenaline in excised femoral arteries of dogs and rats. The responsiveness of these arteries were enhanced after the application of the stimulation. The degree of the hyperresponsiveness was dependent upon frequency, amplitude, and duration of the stimulation. Based on the experimental results, a possible explanation was offered for Raynaud's phenomenon in vibration disease.