Anatomically based geometric modelling of the musculo-skeletal system and other organs
Anatomically based geometric modelling of the musculo-skeletal system and other organs
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DOI：
10.1007/s10237-003-0036-1
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发表时间：
2004-03-01
影响因子：
3.5
通讯作者：
Hunter, P. J.
中科院分区：
文献类型：
--
作者：
Fernandez, J. W.;Mithraratne, P.;Hunter, P. J.
基于解剖学的有限元几何形状在生理建模中越来越受欢迎，这是由于将器官功能与蛋白质、细胞和组织水平的空间分布特性联系起来的建模需求。我们提出了一个基于解剖学的肌肉骨骼系统和其他器官的有限元几何形状的集合，适用于连续分析。这些网格来自广泛使用的可视人体（VH）数据集，并构成了对世界范围内国际生理科学联合会（IUPS）生理组计划（www.physiome.org.nz）的贡献。网格生成和拟合的三次Hermite体积网格到一个给定的数据集的方法说明了使用最小二乘算法，该算法是修改与平滑（Sobolev）的约束，通过惩罚的方法来考虑稀疏和分散的数据。基于“自由形式”变形（FFD）的技术（“宿主网格”拟合）用于定制拟合的（通用）几何体。以肺叶、股直肌和下肢骨为例，说明了这些方法。下肢、膝关节、前臂和颈部的几何形状也被提出。最后，讨论了这些方法的问题和局限性。
Anatomically based finite element geometries are becoming increasingly popular in physiological modelling, owing to the demand for modelling that links organ function to spatially distributed properties at the protein, cell and tissue level. We present a collection of anatomically based finite element geometries of the musculo-skeletal system and other organs suitable for use in continuum analysis. These meshes are derived from the widely used Visible Human (VH) dataset and constitute a contribution to the world wide International Union of Physiological Sciences (IUPS) Physiome Project (www.physiome.org.nz). The method of mesh generation and fitting of tricubic Hermite volume meshes to a given dataset is illustrated using a least-squares algorithm that is modified with smoothing (Sobolev) constraints via the penalty method to account for sparse and scattered data. A technique ("host mesh" fitting) based on "free-form" deformation (FFD) is used to customise the fitted (generic) geometry. Lung lobes, the rectus femoris muscle and the lower limb bones are used as examples to illustrate these methods. Geometries of the lower limb, knee joint, forearm and neck are also presented. Finally, the issues and limitations of the methods are discussed.