Age differences in prefrontal cortical activity in working memory.
Age differences in prefrontal cortical activity in working memory.
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DOI：
10.1037//0882-7974.16.3.371
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发表时间：
2001-09
影响因子：
3.7
通讯作者：
B. Rypma;V. Prabhakaran;J. Desmond;J. Gabrieli
中科院分区：
文献类型：
--
作者：
B. Rypma;V. Prabhakaran;J. Desmond;J. Gabrieli
工作记忆（WM）随着年龄的增长而下降。脑成像研究表明，当信息被保留在WM中时，腹侧前额叶皮层（PFC）是活跃的，而背侧前额叶皮层（PFC）在保留大量信息时进一步被激活。作者检查了衰老对WM表现期间特定PFC区域激活的影响。6名年轻人和6名老年人分别完成了一项任务，在每次试验中，他们(a)编码1个或6个字母的记忆集，(b)将这些字母保持在5秒以上。(c)确定探测字母是否为存储集的一部分。1字母和6字母条件下的激活比较表明，腹侧PFC的激活与年龄相当。年轻人比老年人表现出更大的PFC背侧激活。老年人的吻侧PFC比年轻人更活跃。衰老可能影响对WM执行成分很重要的PFC脑背区。
Working memory (WM) declines with advancing age. Brain imaging studies indicate that ventral prefrontal cortex (PFC) is active when information is retained in WM and that dorsal PFC is further activated for retention of large amounts of information. The authors examined the effect of aging on activation in specific PFC regions during WM performance. Six younger and 6 older adults performed a task in which, on each trial, they (a) encoded a 1- or 6-letter memory set, (b) maintained these letters over 5-s. and (c) determined whether or not a probe letter was part of the memory set. Comparisons of activation between the 1- and 6-letter conditions indicated age-equivalent ventral PFC activation. Younger adults showed greater dorsal PFC activation than older adults. Older adults showed greater rostral PFC activation than younger adults. Aging may affect dorsal PFC brain regions that are important for WM executive components.