FAMILIAL ELEVATION OF PLASMA HISTIDINE-RICH GLYCOPROTEIN IN A FAMILY WITH THROMBOPHILIA
FAMILIAL ELEVATION OF PLASMA HISTIDINE-RICH GLYCOPROTEIN IN A FAMILY WITH THROMBOPHILIA
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DOI：
10.1111/j.1365-2141.1987.tb02357.x
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发表时间：
1987-11-01
影响因子：
6.5
通讯作者：
BROMMER, EJP
中科院分区：
文献类型：
--
作者：
ENGESSER, L;KLUFT, C;BROMMER, EJP
对一名患有自发性静脉血栓事件、心肌梗塞和血栓形成阳性家族史的患者进行了潜在止血疾病的调查。发现了异常高水平的富含组氨酸的糖蛋白。不存在其他已知或怀疑会增加血栓形成风险的异常情况。该家族的其他四名成员在两代人中似乎都存在富含组氨酸的糖蛋白水平升高，这表明存在遗传性疾病。需要进一步研究富含组氨酸的糖蛋白水平升高与血栓形成的关系。
A patient with spontaneous venous thrombotic events, myocardial infarction and a positive family history of thrombosis was investigated for underlying disorders of haemostasis. Abnormally high levels of histidine-rich glycoprotein were found. No other abnormality known or suspected of increasing the risk for thrombosis was present. Elevated levels of histidine-rich glycoprotein appeared to be present in four other members of the family over two generations suggesting a hereditary disorder. Further study on the relation of elevated histidine-rich glycoprotein levels and thrombosis is indicated.