Comparative effects of two different forms of selenium on oxidative stress biomarkers in healthy men: a randomized clinical trial.
Comparative effects of two different forms of selenium on oxidative stress biomarkers in healthy men: a randomized clinical trial.
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两种不同形式的硒对健康男性氧化应激生物标志物的比较影响：一项随机临床试验。
DOI：
10.1158/1940-6207.capr-14-0042
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发表时间：
2014
期刊：
影响因子：
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通讯作者：
El-Bayoumy,Karam
中科院分区：
文献类型：
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作者：
RichieJr,JohnP;Das,Arun;Calcagnotto,AnaM;Sinha,Raghu;Neidig,Wanda;Liao,Jiangang;Lengerich,EugeneJ;Berg,Arthur;Hartman,TerrylJ;Ciccarella,Amy;Baker,Aaron;Kaag,MatthewG;Goodin,Susan;DiPaola,RobertS;El-Bayoumy,Karam
流行病学和实验室研究表明，膳食硒可预防前列腺癌。临床试验结果表明，富硒酵母（SY）而不是硒蛋氨酸（SeMet）可能有效降低前列腺癌风险。我们的目标是首次直接比较SeMet和SY对男性前列腺癌相关生物标志物的影响。我们在69名健康男性中进行了一项随机双盲、安慰剂对照试验，分别给予SY（200或285 μg/天）和SeMet（200 μg/天）9个月。主要终点包括含硒化合物和氧化应激生物标志物[尿8-羟基-2 ′-脱氧鸟苷（8-OHdG）和8-异前列腺素-F2α（8-iso-PGF 2 α）和血谷胱甘肽（GSH）]的血液水平。次要终点包括血糖和PSA水平。所有组的依从性都很高（>95%）。治疗9个月后，硒蛋氨酸组、低剂量组和高剂量组血浆硒水平分别升高93%、54%和86%，洗脱3个月后恢复至基线水平（P< 0.05）。SY高剂量组治疗9个月后8-OHdG和8-iso-PGF 2 α水平分别下降34%和28%（P< 0.05）。这些下降在基线血浆硒水平低（<127 ng/mL）的个体中最大。未观察到血清PSA或血糖和GSH的变化。总的来说，我们首次发现，在健康男性中补充SY而不是SeMet后，氧化应激生物标志物减少。这些发现表明，除SeMet外的含硒化合物可能是氧化应激降低的原因。Cancer Prev Res; 7（8）; 796-804。©2014 AACR.
Epidemiologic and laboratory studies indicate that dietary selenium protects against prostate cancer. Results from clinical trials suggest that selenium-enriched yeast (SY) but not selenomethionine (SeMet) may be effective at reducing prostate cancer risk. Our objectives were to directly compare for the first time the effects of SeMet and SY on prostate cancer relevant biomarkers in men. We performed a randomized double blind, placebo-controlled trial of SY (200 or 285 μg/day) and SeMet (200 μg/day) administered for 9 months in 69 healthy men. Primary endpoints included blood levels of selenium-containing compounds and oxidative stress biomarkers [urine 8-hydroxy-2′-deoxyguanosine (8-OHdG) and 8-iso-prostaglandin-F2α(8-iso-PGF2α) and blood glutathione (GSH)]. Secondary endpoints included plasma glucose and PSA levels. Compliance was high in all groups (>95%). Plasma selenium levels were increased 93%, 54%, and 86% after 9 months in SeMet and low- and high-dose SY groups, respectively, and returned to baseline levels after a 3-month washout (P< 0.05). Levels of 8-OHdG and 8-iso-PGF2αwere decreased 34% and 28%, respectively, after 9 months in the high-dose SY group (P< 0.05). These decreases were greatest in individuals with low baseline plasma levels of selenium (<127 ng/mL). No changes in serum PSA or blood glucose and GSH were observed. Overall, we showed for the first time, reductions in biomarkers of oxidative stress following supplementation with SY but not SeMet in healthy men. These findings suggest that selenium-containing compounds other than SeMet may account for the decrease in oxidative stress.Cancer Prev Res; 7(8); 796–804. ©2014 AACR.