ANTIBODY TO ACETYLCHOLINE-RECEPTOR IN MYASTHENIA-GRAVIS - PREVALENCE, CLINICAL CORRELATES, AND DIAGNOSTIC VALUE
ANTIBODY TO ACETYLCHOLINE-RECEPTOR IN MYASTHENIA-GRAVIS - PREVALENCE, CLINICAL CORRELATES, AND DIAGNOSTIC VALUE
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DOI：
10.1212/wnl.26.11.1054
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发表时间：
1976-01-01
期刊：
影响因子：
9.9
通讯作者：
DUANE, DD
中科院分区：
文献类型：
--
作者：
LINDSTROM, JM;SEYBOLD, ME;DUANE, DD
在71例重症肌无力患者的87%血清中检测到乙酰胆碱受体特异性抗体升高，但在175例无重症肌无力患者的血清中未检测到乙酰胆碱受体特异性抗体升高，包括其他神经系统或自身免疫性疾病患者。抗受体抗体不针对受体的乙酰胆碱结合位点。抗体滴度的存在似乎与年龄、性别、类固醇治疗或症状持续时间无关。仅出现眼部症状的重症肌无力患者抗体滴度较低，而合并胸腺瘤的重症肌无力患者的大多数滴度超过了重症肌无力组整体的中位滴度。抗受体抗体测定对重症肌无力的诊断有一定的价值。
Elevated amounts of antibodies specific for acetylcholine receptors were detected in 87% of sera from 71 patients with myasthenia gravis but not in 175 sera from individuals without myasthenia gravis, including those with other neurologic or autoimmune diseases. Antireceptor antibodies were not directed at the acetylcholine binding site of the receptor. Presence of titer of antibody did not appear to correlate with age, sex, steroid therapy or duration of symptoms. Myasthenia gravis patients with only ocular symptoms had lower antibody titers, while the majority of titers in myasthenia gravis patients with thymoma exceeded the median titer of the myasthenia gravis group as a whole. Assay of antireceptor antibody should prove to be a useful test in the dignosis of myasthenia gravis.