The long‐term prognostic significance of the thymidine labelling index in breast cancer
The long‐term prognostic significance of the thymidine labelling index in breast cancer
复制标题
胸苷标记指数对乳腺癌长期预后的意义
DOI：
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发表时间：
1984
影响因子：
6.4
通讯作者：
E. Malaise
中科院分区：
文献类型：
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作者：
M. Tubiana;M. Pejovic;N. Chavaudra;G. Contesso;E. Malaise
1972年进行了一项关于标签指数（LI）预后意义的前瞻性研究。128例乳腺癌患者在初始治疗时连续测定原发肿瘤的LI，然后用氚化胸腺嘧啶体外孵育标本。所有患者的随访现已延长至10年以上。低LI患者的无复发生存期和总生存期明显更高。采用Cox模型对预后因素进行多变量分析，结果显示Li是最能预测生存率的指标。肿瘤的大小是第二大预测指标，而组织学分级和受累淋巴结的数量则不太具有预测性。这些结果强烈表明，LI评估的增殖活性与转移传播概率直接相关，独立于其他预后因素。
A prospective study of the prognostic significance of the labelling index (LI) was undertaken in 1972. The LI of the primary tumor was measured consecutively on 128 patients with mammary carcinoma at the time of initial treatment, following in vitro incubation of specimens with tritiated thymidine. The follow‐up for all patients has now extended over 10 years. Relapse‐free survival and total survival are significantly higher in patients with a low LI. A multivariate analysis of the prognostic factors, carried out with Cox's model, showed that Li is the most predictive indicator with respect to survival. The size of the tumor is the second most predictive indicator, while histological grading and the number of involved lymph nodes are less predictive. These results strongly suggest that proliferative activity as assessed by LI is directly related to metastatic dissemination probability, independent of other prognostic factors.
DOI：
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发表时间：
1972
期刊：
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影响因子：
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作者：
D. Cox
通讯作者：
D. Cox