Impact of smoking on bone mineral density and bone metabolism in elderly men: the Fujiwara-kyo Osteoporosis Risk in Men (FORMEN) study
Impact of smoking on bone mineral density and bone metabolism in elderly men: the Fujiwara-kyo Osteoporosis Risk in Men (FORMEN) study
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DOI：
10.1007/s00198-010-1238-x
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发表时间：
2011-01-01
影响因子：
4
通讯作者：
Kurumatani, N.
中科院分区：
文献类型：
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作者：
Tamaki, J.;Iki, M.;Kurumatani, N.
我们对1,576名年龄为千分之一日元65岁的男性进行了横断面分析，研究了吸烟对骨骼状况的影响。在调整年龄、身高、体重和每日吸烟量后，吸烟年数与骨密度（BMD）降低相关。吸烟并不影响骨转换的血清生化标志物值。吸烟对男性骨状态的影响还没有最终确定。我们研究了吸烟和戒烟如何影响男性的骨状态和代谢。我们分析了2007- 2008年期间进行的藤原京男性骨质疏松风险研究中的1,576名男性，该研究对年龄为千分之一日元65岁的日本男性进行了基线调查。从不吸烟、以前吸烟和现在吸烟的男性腰椎（LS）BMD值为1.045 +/- 0.194，1.030 ± 0.189和1.001 ± 0.182 g/cm 2（P = 0.005），而全髋（TH）BMD值分别为0.888 ± 0.120、0.885 ± 0.127和0.870 ± 0.124（P = 0.078）。校正协变量后，LS BMD的显著趋势仍然存在;年龄，身高，体重，体力活动，牛奶消耗量和饮酒习惯（P = 0.036）。在从未和曾经（当前和以前）吸烟者中，LS和TH BMD分别随烟包年数或吸烟年数的增加而降低，并对这些协变量进行了调整。在曾经吸烟者中，LS和TH BMD在调整年龄、身高、体重和每日吸烟数量后随着吸烟年数的增加而降低。吸烟对老年男性骨钙素和抗酒石酸酸性磷酸酶同工酶5 b的影响不显著，吸烟对老年男性骨状况的影响主要与吸烟年限有关。
Our cross-sectional analysis of 1,576 men aged a parts per thousand yen65 years examined smoking effects on bone status. Number of smoking years was associated with decreased bone mineral density (BMD), after adjusting for age, height, weight, and number of cigarettes smoked daily. Smoking did not affect biochemical marker serum values for bone turnover.The impact of smoking on bone status in men has not been conclusively established. We examined how smoking and its cessation influence bone status and metabolism in men.We analyzed 1,576 men among a baseline survey of Japanese men aged a parts per thousand yen65 years, the Fujiwara-kyo Osteoporosis Risk in Men study, conducted during 2007-2008.Lumbar spine (LS) BMD values among never, former, and current smokers were 1.045 +/- 0.194, 1.030 +/- 0.189, and 1.001 +/- 0.182 g/cm(2) (P = 0.005), respectively, while total hip (TH) BMD values were 0.888 +/- 0.120, 0.885 +/- 0.127, and 0.870 +/- 0.124 (P = 0.078), respectively. The significant trend for LS BMD remained after adjusting for the covariates; age, height, weight, physical activity, milk consumption, and drinking habit (P = 0.036). Among never and ever (current and former) smokers, LS and TH BMD decreased with the number of pack years or the number of smoking years, respectively, adjusted for those covariates. Among ever smokers, LS and TH BMD decreased with the number of smoking years after adjusting for age, height, weight, and number of cigarettes smoked daily. Smoking did not reveal significant effect for serum osteocalcin or tartrate resistant acid phosphatase isoenzyme 5b.The impact of smoking on bone status is mainly associated with the number of smoking years in elderly men.