The therapeutic effect of mesenchymal stem cell transplantation in experimental autoimmune encephalomyelitis is mediated by peripheral and central mechanisms.
The therapeutic effect of mesenchymal stem cell transplantation in experimental autoimmune encephalomyelitis is mediated by peripheral and central mechanisms.
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DOI：
10.1186/scrt94
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发表时间：
2012-01-26
影响因子：
7.5
通讯作者：
Uccelli A
中科院分区：
文献类型：
--
作者：
Morando S;Vigo T;Esposito M;Casazza S;Novi G;Principato MC;Furlan R;Uccelli A
干细胞目前被视为治疗多发性硬化症等神经系统疾病的组织再生的方法，预计它们会整合并分化为神经细胞。间充质干细胞 (MSC) 是成体祖细胞的一个子集，可分化为中胚层谱系的细胞，但在某些实验环境下，也可分化为神经元和神经胶质谱系的细胞。然而，间充质干细胞显示出主要通过旁观者机制发生的显着治疗可塑性，显着促进了它们的临床发展。这些特征已被用于有效治疗实验性自身免疫性脑脊髓炎，这是一种多发性硬化症的动物模型，其中自身免疫反应的抑制导致疾病显着改善并减少脱髓鞘、免疫浸润和轴突损失。令人惊讶的是，这些作用并不需要间充质干细胞植入中枢神经系统，而是取决于细胞抑制中枢神经系统外周和内部致病性免疫反应以及释放有利于组织修复的神经保护和促少突胶质细胞分子的能力。这些结果为利用间充质干细胞治疗多发性硬化症铺平了道路。
Stem cells are currently seen as a treatment for tissue regeneration in neurological diseases such as multiple sclerosis, anticipating that they integrate and differentiate into neural cells. Mesenchymal stem cells (MSCs), a subset of adult progenitor cells, differentiate into cells of the mesodermal lineage but also, under certain experimental circumstances, into cells of the neuronal and glial lineage. Their clinical development, however, has been significantly boosted by the demonstration that MSCs display significant therapeutic plasticity mainly occurring through bystander mechanisms. These features have been exploited in the effective treatment of experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis where the inhibition of the autoimmune response resulted in a significant amelioration of disease and decrease of demyelination, immune infiltrates and axonal loss. Surprisingly, these effects do not require MSCs to engraft in the central nervous system but depend on the cells' ability to inhibit pathogenic immune responses both in the periphery and inside the central nervous system and to release neuroprotective and pro-oligodendrogenic molecules favoring tissue repair. These results paved the road for the utilization of MSCs for the treatment of multiple sclerosis.
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影响因子：
2.6
作者：
Bartholomew, A;Sturgeon, C;Hoffman, R
通讯作者：
Hoffman, R
影响因子：
5.2
作者：
Constantin, Gabriela;Marconi, Silvia;Bonetti, Bruno
通讯作者：
Bonetti, Bruno
影响因子：
4.4
作者：
Ghannam, Soufiane;Pene, Jerome;Yssel, Hans
通讯作者：
Yssel, Hans
DOI：
10.1073/pnas.0508945102
发表时间：
2005-12-13
影响因子：
11.1
作者：
Munoz, JR;Stoutenger, BR;Prockop, DJ
通讯作者：
Prockop, DJ
影响因子：
4
作者：
Lanz, Tobias V.;Opitz, Christiane A.;Platten, Michael
通讯作者：
Platten, Michael