Mathematical modelling of the pathogenesis of multiple myeloma-induced bone disease.
Mathematical modelling of the pathogenesis of multiple myeloma-induced bone disease.
复制标题
多发性骨髓瘤引起的骨病发病机制的数学模型
DOI：
10.1002/cnm.2645
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发表时间：
2014-11
影响因子：
2.1
通讯作者：
Fagan MJ
中科院分区：
文献类型：
--
作者：
Ji B;Genever PG;Patton RJ;Fagan MJ
多发性骨髓瘤 (MM) 是第二常见的血液恶性肿瘤，会导致破坏性骨病变。 MM细胞与骨微环境之间的相互作用在肿瘤细胞和MM诱导的骨疾病的发展中起着重要作用，并形成肿瘤发展和骨破坏的“恶性循环”，并通过抑制成骨细胞活性和促进破骨细胞活性而加剧。在本文中，提出了一个数学模型来模拟MM细胞与骨微环境之间的相互作用如何促进肿瘤细胞的发育以及由此产生的骨破坏。它包括抑制成骨细胞活性和刺激破骨细胞活性的作用。该模型能够模拟肿瘤细胞侵入并去除后骨细胞浓度和骨体积的时间变化，并解释了为什么 MM 引起的骨病变即使在完全去除 MM 细胞后也很少愈合。该模型的行为与已发表的实验数据非常吻合。该模型是了解 MM 诱发的骨病发展的第一步，可进一步应用于评估当前针对 MM 诱发的骨病的治疗方法，甚至提出新的潜在治疗靶点。 © 2014 作者。 John Wiley & Sons Ltd 出版的《国际生物医学工程数值方法杂志》
Multiple myeloma (MM) is the second most common haematological malignancy and results in destructive bone lesions. The interaction between MM cells and the bone microenvironment plays an important role in the development of the tumour cells and MM-induced bone disease and forms a ‘vicious cycle’ of tumour development and bone destruction, intensified by suppression of osteoblast activity and promotion of osteoclast activity. In this paper, a mathematical model is proposed to simulate how the interaction between MM cells and the bone microenvironment facilitates the development of the tumour cells and the resultant bone destruction. It includes both the roles of inhibited osteoblast activity and stimulated osteoclast activity. The model is able to mimic the temporal variation of bone cell concentrations and resultant bone volume after the invasion and then removal of the tumour cells and explains why MM-induced bone lesions rarely heal even after the complete removal of MM cells. The behaviour of the model compares well with published experimental data. The model serves as a first step to understand the development of MM-induced bone disease and could be applied further to evaluate the current therapies against MM-induced bone disease and even suggests new potential therapeutic targets. © 2014 The Authors. International Journal for Numerical Methods in Biomedical Engineering published by John Wiley & Sons Ltd
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影响因子：
4.1
作者：
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通讯作者：
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