Anterior cingulate cortex differently modulates frontoparietal functional connectivity between resting-state and working memory tasks
Anterior cingulate cortex differently modulates frontoparietal functional connectivity between resting-state and working memory tasks
复制标题
前扣带皮层不同地调节静息状态和工作记忆任务之间的额顶叶功能连接
DOI：
10.1002/hbm.24912
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发表时间：
2020-01-06
影响因子：
4.8
通讯作者：
Biswal, Bharat B.
中科院分区：
文献类型：
--
作者：
Di, Xin;Zhang, Heming;Biswal, Bharat B.
大脑额顶叶区域和它们之间的功能性通信对于支持工作记忆和其他执行功能至关重要。额顶叶区域之间的功能连接受到工作记忆负荷的调节，并且在静息状态下受到第三脑区的调节。然而，它在很大程度上是未知的第三区域调制保持不变，在工作记忆任务或在很大程度上调制的任务要求。在本研究中，我们收集了功能磁共振成像（fMRI）数据时，被试执行n-back任务，并在休息状态。我们首先使用一个块设计的定位器来定义额顶叶区域，该区域在2-back条件下比1-back条件下显示出更高的激活。接下来，我们进行了生理生理相互作用（PPI）分析，分别使用左，右额中回（MFG）和上级顶叶小叶（SPL）地区，在三个连续设计的运行的休息状态，1-回，2-回条件。在这三种条件下，没有一个区域表现出与种子对一致的调节相互作用。相反，前扣带皮层（ACC）表现出不同的调制与右MFG和SPL之间的相互作用的三种条件。虽然ACC的活性增加与静息状态下右侧MFG和SPL之间的功能耦合减少相关，但它与2-back条件下的功能耦合增加相关。所观察到的任务调制支持的功能意义的前扣带回的调制额顶连接。
The brain frontoparietal regions and the functional communications between them are critical in supporting working memory and other executive functions. The functional connectivity between frontoparietal regions are modulated by working memory loads, and are shown to be modulated by a third brain region in resting-state. However, it is largely unknown whether the third-region modulations remain the same during working memory tasks or were largely modulated by task demands. In the current study, we collected functional MRI (fMRI) data when the subjects were performing n-back tasks and in resting-state. We first used a block-designed localizer to define the frontoparietal regions that showed higher activations in the 2-back than the 1-back condition. Next, we performed physiophysiological interaction (PPI) analysis using left and right middle frontal gyrus (MFG) and superior parietal lobule (SPL) regions, respectively, in three continuous-designed runs of resting-state, 1-back, and 2-back conditions. No regions showed consistent modulatory interactions with the seed pairs in the three conditions. Instead, the anterior cingulate cortex (ACC) showed different modulatory interactions with the right MFG and SPL among the three conditions. While the increased activity of the ACC was associated with decreased functional coupling between the right MFG and SPL in resting-state, it was associated with increased functional coupling in the 2-back condition. The observed task modulations support the functional significance of the modulations of the ACC on frontoparietal connectivity.