Motor cortical inhibition in ADHD: modulation of the transcranial magnetic stimulation-evoked N100 in a response control task
Motor cortical inhibition in ADHD: modulation of the transcranial magnetic stimulation-evoked N100 in a response control task
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DOI：
10.1007/s00702-013-1097-7
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发表时间：
2014-03-01
影响因子：
3.3
通讯作者：
Heinrich, Hartmut
中科院分区：
文献类型：
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作者：
D'Agati, Elisa;Hoegl, Thomas;Heinrich, Hartmut
经颅磁刺激（TMS）和脑电图诱发的N100成分与抑制性皮层回路的激活有关，最近被认为是注意缺陷/多动障碍（ADHD）抑制的潜在标志。本研究的目的是探讨在反应控制任务的go和nogo试验中TMS-N100的调节，考虑反应准备、激活、执行和抑制阶段。18名患有多动症的儿童和19名发育正常的儿童，年龄在10-14岁之间。经颅磁刺激经左侧运动皮层传递，在P3电极测量TMS- n100。在提示去/不去任务（S1-S2范式）中，测定静息和不同时间点（S2前50 ms， S2后150、300和500 ms）的TMS-N100。计算TMS- n100测量值、mep相关TMS测量值（如短间隔皮质内抑制）和表现测量值之间的相关性。静息时，ADHD组TMS-N100的振幅未见明显降低。在go/nogo任务中，ADHD儿童在go试验中TMS-N100振幅的增加幅度较小，抑制反应后TMS-N100振幅的下降幅度较小。在围棋试验中，较低的TMS-N100与较小的反应时间变异性相关。较小的TMS-N100调节扩展了ADHD的皮质抑制缺陷。研究结果表明，TMS-N100在运动输出阶段的功能参与机制。
The N100 component, evoked by transcranial magnetic stimulation (TMS) and electroencephalography is associated with the activation of inhibitory cortical circuits and has recently been suggested as a potential marker of inhibition in attention-deficit/hyperactivity disorder (ADHD). The aim of the present ADHD study was to investigate the modulation of the TMS-N100 in go and nogo trials of a response control task considering stages of response preparation, activation, execution and inhibition. Eighteen children with ADHD and 19 typically developing children, aged 10-14 years, were assessed. TMS was delivered over the left motor cortex, the TMS-N100 was measured at electrode P3. The TMS-N100 was determined at rest and at different time points (50 ms before S2; 150, 300 and 500 ms after S2) in a cued go/nogo task (S1-S2 paradigm). Correlations between the TMS-N100 measures, MEP-related TMS measures (e.g., short-interval intracortical inhibition) and performance measures were calculated. At rest, the amplitude of TMS-N100 was not found to be significantly reduced in the ADHD group. During the go/nogo task, children with ADHD showed a smaller increase of TMS-N100 amplitude in go trials and a smaller decrease after inhibiting a response. In go trials, a lower TMS-N100 was associated with a smaller variability of reaction times. A smaller TMS-N100 modulation extends the picture of cortical inhibition deficits in ADHD. Findings suggest a functional involvement of the mechanisms underlying the TMS-N100 at the motor output stage.