Simultaneous PET–MR acquisition and MR-derived motion fields for correction of non-rigid motion in PET
Simultaneous PET–MR acquisition and MR-derived motion fields for correction of non-rigid motion in PET
复制标题
同时 PET-MR 采集和 MR 导出的运动场用于校正 PET 中的非刚性运动
DOI：
--
复制
发表时间：
2010
影响因子：
2.6
通讯作者：
P. Marsden
中科院分区：
文献类型：
--
作者：
C. Tsoumpas;J. Mackewn;P. Halsted;A. King;C. Buerger;J. Totman;T. Schaeffter;P. Marsden
目的 正电子发射断层扫描 (PET) 可以准确测量体内放射性示踪剂浓度，但性能可能会受到对象运动的限制，从而降低空间分辨率和定量准确性。随着 PET 扫描仪技术的改进，这种效应可能成为体内 PET 研究的限制因素。在这项工作中，我们提出了一种新方法来解决这个问题，即利用磁共振 (MR) 扫描仪同时测量的图像中的运动信息。方法该方法通过使用 MR 兼容 PET 扫描仪和 PET-MR 采集以及专门设计的能够非刚性变形的体模进行演示。使用测量的、同时采集的 MR 数据来校正 PET 中的运动，并将结果与仅使用 PET 图像的运动信息获得的结果进行比较。结果通过使用 MR 运动场，运动伪影显着减少，PET 图像质量和量化显着改善，而仅使用 PET 运动信息不太成功。结论 组合 PET-MR 采集可能允许在全身采集中进行 PET 运动补偿，而无需延长 PET 采集时间或增加辐射剂量。据我们所知，这是第一项证明同时采集的 MR 数据可用于估计和校正 PET 中非刚性运动影响的研究。
ObjectivePositron emission tomography (PET) provides an accurate measurement of radiotracer concentration in vivo, but performance can be limited by subject motion which degrades spatial resolution and quantitative accuracy. This effect may become a limiting factor for PET studies in the body as PET scanner technology improves. In this work, we propose a new approach to address this problem by employing motion information from images measured simultaneously using a magnetic resonance (MR) scanner.MethodsThe approach is demonstrated using an MR-compatible PET scanner and PET–MR acquisition with a purpose-designed phantom capable of non-rigid deformations. Measured, simultaneously acquired MR data were used to correct for motion in PET, and results were compared with those obtained using motion information from PET images alone.ResultsMotion artefacts were significantly reduced and the PET image quality and quantification was significantly improved by the use of MR motion fields, whilst the use of PET-only motion information was less successful.ConclusionsCombined PET–MR acquisitions potentially allow PET motion compensation in whole-body acquisitions without prolonging PET acquisition time or increasing radiation dose. This, to the best of our knowledge, is the first study to demonstrate that simultaneously acquired MR data can be used to estimate and correct for the effects of non-rigid motion in PET.
影响因子：
2.8
作者：
Loening, Andreas Markus;Gambhir, Sanjiv Sam
通讯作者：
Gambhir, Sanjiv Sam