Inflammation and thrombosis in essential thrombocythemia and polycythemia vera: different role of C-reactive protein and pentraxin 3
Inflammation and thrombosis in essential thrombocythemia and polycythemia vera: different role of C-reactive protein and pentraxin 3
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DOI：
10.3324/haematol.2010.031070
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发表时间：
2011-02-01
期刊：
影响因子：
--
通讯作者：
Rambaldi, Alessandro
中科院分区：
文献类型：
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作者：
Barbui, Tiziano;Carobbio, Alessandra;Rambaldi, Alessandro
我们检验了以下假设：在原发性血小板增多症和真性红细胞增多症患者中，正五聚蛋白高敏C反应蛋白和正五聚蛋白3的水平可能与心血管并发症相关。对244例连续的原发性血小板增多症和真性红细胞增多症患者进行了高敏C反应蛋白和正五聚蛋白3检测，中位随访时间为5.3年（范围0-24年），诊断出68例心血管事件。最高C反应蛋白三分位数与最低C反应蛋白三分位数（> 3 vs < 1 mg/L）进行比较，并与年龄（P=0.001）、表型（真性红细胞增多症vs原发性血小板增多症，P=0.006）、心血管危险因素（P=0.012）和JAK 2 V617 F等位基因负荷大于50%（P=0.003）相关。C-反应蛋白三分位数最高组的严重血栓形成率较高（P=0.01），五聚蛋白3水平最高组的严重血栓形成率较低（P=0.045）。这些相关性在多变量分析中仍然显着，表明高敏C反应蛋白和petraxin 3的血液水平独立地以相反的方式调节骨髓增生性疾病患者心血管事件的内在风险。
We tested the hypothesis that levels of pentraxin high sensitivity C-reactive protein and pentraxin 3 might be correlated with cardiovascular complications in patients with essential thrombocythemia and polycythemia vera. High sensitivity C-reactive protein and pentraxin 3 were measured in 244 consecutive essential thrombocythemia and polycythemia vera patients in whom, after a median follow up of 5.3 years (range 0-24), 68 cardiovascular events were diagnosed. The highest C-reactive protein tertile was compared with the lowest (> 3 vs. < 1 mg/L) and correlated with age (P=0.001), phenotype (polycythemia vera vs. essential thrombocythemia, P=0.006), cardiovascular risk factors (P=0.012) and JAK2V617F allele burden greater than 50% (P=0.003). Major thrombosis rate was higher in the highest C-reactive protein tertile (P=0.01) and lower at the highest pentraxin 3 levels (P=0.045). These associations remained significant in multivariate analyses and indicate that blood levels of high sensitivity C-reactive protein and petraxin 3 independently and in opposite ways modulate the intrinsic risk of cardiovascular events in patients with myeloproliferative disorders.