Experimental radiation synovectomy by 165Dy ferric hydroxide macroaggregate.
Experimental radiation synovectomy by 165Dy ferric hydroxide macroaggregate.
复制标题
165Dy 氢氧化铁大聚集体实验性放射滑膜切除术。
作者：
C. Sledge;J. Noble;D. Hnatowich;R. Kramer;S. Shortkroff
半衰期短的 β 发射体 165Dy 与氢氧化铁 (FHMA) 共沉淀为大聚集体，已被证明可以破坏抗原诱导的关节炎兔的膝关节滑膜。使用 153Gd 作为伽马示踪剂进行泄漏研究表明，该系统从兔子膝关节的泄漏在 24 小时内从未超过 1.2%。这比任何人类研究或我们使用 198Au 的兔子研究报告的泄漏率都要低。
The short half-life beta emitter 165Dy coprecipitated as a macroaggregate with ferric hydroxide (FHMA) has been shown to destroy knee synovium in the antigen-induced arthritic rabbit. Using 153Gd as a gamma tracer for leakage studies revealed that the leakage of this system from rabbit knee joints never exceeded 1.2% over 24 hours. This is such less than the leakage rates reported from any human studies or our rabbit studies using 198Au.