Curvulaide A, a bicyclic polyketide with anti-anaerobic bacteria activity from marine-derived Curvularia sp.
Curvulaide A, a bicyclic polyketide with anti-anaerobic bacteria activity from marine-derived Curvularia sp.
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Curvulaide A 是一种双环聚酮化合物，具有抗厌氧菌活性，源自海洋弯孢菌属。
DOI：
10.1038/s41429-018-0110-7
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发表时间：
2019-02-01
影响因子：
3.3
通讯作者：
Lu, Yan-Hua
中科院分区：
文献类型：
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作者：
Liu, Wei-He;Ding, Yi;Lu, Yan-Hua
IFB-Z10。通过一维和二维核磁共振数据、高分辨电喷雾电离质谱学、电子圆二色谱(ECD)实验和计算，确定了化合物1的结构。曲霉内酯A(1)对牙周病原菌牙龈卟啉单胞菌有中等抗厌氧菌活性，MIC值为62.5 μM；对人肝癌细胞株BEL7402/5-FU有中等细胞毒作用，IC50值为12.46 μM。
IFB-Z10. The structure of 1 was elucidated using a combination of spectral methods, including extensive one-dimensional (1D) and two-dimensional (2D) nuclear magnetic resonance (NMR) data, high resolution electrospray ionization mass spectrometry (HRESIMS), experimental and calculated electronic circular dichroism (ECD) spectra. Curvulaide A (1) exhibited moderate anti-anaerobic bacteria activity against periodontal pathogen Porphyromonas gingivalis with the MIC value of 62.5 μM, and showed moderate cytotoxicity against human hepatoma cell lines BEL7402/5-Fu with IC50 values of 12.46 μM.