MR Features Based on LI-RADS Ver. 2018 Correlated with Cytokeratin 19 Expression in Combined Hepatocellular Carcinoma-Cholangiocarcinoma.
MR Features Based on LI-RADS Ver. 2018 Correlated with Cytokeratin 19 Expression in Combined Hepatocellular Carcinoma-Cholangiocarcinoma.
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基于 LI-RADS Ver. 的 MR 功能
DOI：
10.2147/jhc.s325686
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发表时间：
2021
影响因子：
4.1
通讯作者：
Zeng M
中科院分区：
文献类型：
--
作者：
Zhou C;Ni X;Lu X;Wang Y;Qian X;Yang C;Zeng M
探讨基于肝脏影像报告和数据系统（LI-RADS ver.）的MR特征的意义。2018），用于确定术前肝细胞癌-胆管细胞癌（cHCC-CCA）患者中细胞角蛋白19（CK-19）的表达。该研究招募了174名根据2019年WHO分类经病理证实患有cHCC-CCA的患者。回顾性分析CK-19阳性和CK-19阴性的cHCC-CCA患者的术前MR影像学特征和临床病理学表现，并进行比较。评价了174例患者（平均年龄，男性vs女性：56.6 ± 10.0岁vs 54.7 ± 14.2岁）。马赛克结构、靶样外观、胆管扩张、肝包膜回缩和冠状强化在CK-19阳性组中显著更高（所有p < 0.05），而非边缘动脉期高增强（APHE）在CK-19阴性组中更常见（p = 0.04）。单因素分析显示，B型肝炎病毒感染、CEA > 5 ng/mL、肿瘤大小、非边缘APHE、镶嵌结构、靶样外观、胆管扩张、肝包膜回缩和冠状增强是CK-19阳性cHCC-CCA的显著危险因素（所有p < 0.05）。不幸的是，多变量分析显示，只有冠状增强（OR = 2.359，p = 0.03）是与CK-19阳性cHCC-CCA相关的独立危险因素。cHCC-CCA患者的冠状增强与CK-19阳性显著相关。
To investigate the significance of MR features based on the Liver Imaging Reporting and Data System (LI-RADS ver. 2018) for identifying the expression of cytokeratin 19 (CK-19) in patients with combined hepatocellular carcinoma-cholangiocarcinoma (cHCC-CCA) before surgery. The study enrolled 174 patients pathologically confirmed to have cHCC-CCA according to the 2019 WHO classification. The preoperative MR imaging features and clinicopathological findings were retrospectively evaluated and compared between the CK-19-positive and CK-19-negative cHCC-CCA groups. One hundred seventy-four patients (mean age, males vs females: 56.6 ± 10.0 years vs 54.7 ± 14.2 years) were evaluated. The presence of mosaic architecture, targetoid appearance, cholangiectasis, hepatic capsule retraction, and corona enhancement was significantly higher in the CK-19-positive group (all p < 0.05), while nonrim arterial phase hyperenhancement (APHE) was more common in the CK-19-negative group (p = 0.04). The univariate analysis showed that hepatitis B virus infection, CEA > 5 ng/mL, tumor size, nonrim APHE, mosaic architecture, targetoid appearance, cholangiectasis, hepatic capsule retraction, and corona enhancement were significant risk factors for CK-19-positive cHCC-CCA (all p < 0.05). Unfortunately, the multivariate analysis revealed that only corona enhancement (OR = 2.359, p = 0.03) was an independent risk factor associated with CK-19-positive cHCC-CCA. Corona enhancement is significantly correlated with CK-19 positivity in patients with cHCC-CCA.