Increasing hospitalization and death possibly due to Clostridium difficile diarrheal disease
Increasing hospitalization and death possibly due to Clostridium difficile diarrheal disease
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DOI：
10.3201/eid0404.980412
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发表时间：
1998-10-01
影响因子：
11.8
通讯作者：
Calderon, RL
中科院分区：
文献类型：
--
作者：
Frost, F;Craun, GF;Calderon, RL
本研究计算了1985年至1994年每年估计的全国医院出院率和1980年至1992年因细菌、病毒、原生动物和不明肠道病原体导致的年龄调整死亡率。1990年至1994年期间，每个类别的婴幼儿住院率（但不包括死亡率）增加了50%以上。自1988年以来，肠道细菌感染导致的年龄调整死亡率和住院率以及肠道病毒感染导致的住院率有所增加。肠道细菌感染住院率和死亡率的增加是由于在此期间未编码的特定肠道细菌感染率增加了八倍多（ICD9 00849）。为了确定导致这些感染的细菌，研究人员检查了1993年至1996年新墨西哥州洛夫莱斯卫生系统的出院病例和门诊索赔（在1992年之后进行了更详细的编码）。在未编码的肠道病原体引起的疾病中，73%是由艰难梭菌感染引起的。此外，88%的华盛顿州死亡证明（1985年至1996年）编码为未指明的肠道病原体感染（ICD0084），列出了艰难梭菌感染。
This study calculated yearly estimated national hospital discharge (1985 to 1994) and age-adjusted death rates (1980 to 1992) due to bacterial, viral, protozoal, and ill-defined enteric pathogens. Infant and young child hospitalization (but not death) rates in each category increased more than 50% during 1990 to 1994. Age-adjusted death and hospitalization rates due to enteric bacterial infections and hospitalizations due to enteric viral infections have increased since 1988. The increases in hospitalization and death rates from enteric bacterial infections were due to a more than eightfold increase in rates for specified enteric bacterial infections that were uncoded during this period (ICD9 00849). To identify bacterial agents responsible for most of these infections, hospital discharges and outpatient claims (coded with more detail after 1992) were examined for New Mexico's Lovelace Health Systems for 1993 to 1996. Of diseases due to uncoded enteric pathogens, 73% were due to Clostridium difficile infection. Also, 88% of Washington State death certificates (1985 to 1996) coded to unspecified enteric pathogen infections (ICD0084) listed C. difficile infection.