Lysosomotropic agents and cysteine protease inhibitors inhibit scrapie-associated prion protein accumulation
Lysosomotropic agents and cysteine protease inhibitors inhibit scrapie-associated prion protein accumulation
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DOI：
10.1128/jvi.74.10.4894-4897.2000
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发表时间：
2000-05-01
影响因子：
5.4
通讯作者：
Caughey, B
中科院分区：
文献类型：
--
作者：
Doh-Ura, K;Iwaki, T;Caughey, B
我们报道了溶酶体促进剂和半胱氨酸蛋白酶抑制剂抑制羊痒病感染的神经母细胞瘤细胞中抗蛋白酶的普恩蛋白的积聚。这种抑制作用对正常的Prion蛋白质的生物合成或周转没有明显的影响，也没有与Prion蛋白质分子的直接相互作用。这些发现引入了两类新的抑制蛋白形成的抗蛋白酶的普恩蛋白。
We report that lysosomotropic agents and cysteine protease inhibitors inhibited protease resistant prion protein accumulation in scrapie-infected neuroblastoma cells. The inhibition occurred without either apparent effects on normal prion protein biosynthesis or turnover or direct interactions with prion protein molecules. The findings introduce two new classes of inhibitors of the formation of protease-resistant prion protein.