Concomitant functional dyspepsia and irritable bowel syndrome decrease health-related quality of life in gastroesophageal reflux disease
Concomitant functional dyspepsia and irritable bowel syndrome decrease health-related quality of life in gastroesophageal reflux disease
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DOI：
10.1080/00365520701204204
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发表时间：
2007-01-01
影响因子：
1.9
通讯作者：
Samsom, Melvin
中科院分区：
文献类型：
--
作者：
de Vries, Durk R.;Van Herwaarden, Margot A.;Samsom, Melvin
目标。以前的研究报告了胃食道反流症状、功能性消化不良(FD)和肠易激综合征(IBS)之间的重叠。本研究旨在探讨FD和IBS在胃食道反流病(GERD)中的患病率及其对健康相关生活质量(HRQOL)的影响。材料和方法。对经24小时pH测定证实的215例转诊和48例非转诊(非寻求护理)GERD患者的FD、IBS患病率和HRQL进行了问卷调查。采用HRQOL对131名配对对照进行比较。结果。在这组GERD患者中，25%患有FD(荷兰普通人群13-14%)，35%患有IBS(荷兰普通人群0.6-6%)，5%既有FD又有IBS。只有35%的人既没有FD，也没有IBS。在转诊的胃肠道反流病患者中，FD和IBS的患病率更高(p=0.002)。与对照组相比，无FD/IBS的GERD患者在SF-36的9个子量表中只有1个维度的HRQOL得分低于对照组(P
Objective. Previous studies have reported an overlap between gastroesophageal reflux symptoms, functional dyspepsia ( FD) and irritable bowel syndrome ( IBS). The aim of this study was to investigate the prevalence of FD and IBS in gastroesophageal reflux disease ( GERD) and the effect on health-related quality of life ( HRQoL). Material and methods. FD and IBS prevalence and HRQoL were assessed by means of questionnaires in 215 referred and 48 non-referred ( non-care-seeking) GERD patients, proven with 24-h pH-metry. HRQoL in 131 matched controls was used for comparison. Results. In this group of GERD patients 25% had FD ( Dutch general population 13 - 14%), 35% had IBS ( Dutch general population 0.6 - 6%) and 5% had both FD and IBS. Only 35% had neither FD nor IBS. Among referred GERD patients, the prevalence of FD and IBS was higher ( p = 0.002 versus non-referred). Compared with controls, GERD patients without FD/IBS had lower HRQoL scores on only one of the nine SF-36 subscales (p