Chemistry and Biology of Pteridines and Folates
Chemistry and Biology of Pteridines and Folates
复制标题
蝶啶和叶酸的化学和生物学
DOI：
10.1007/978-1-4615-0945-5
复制
发表时间：
2002
影响因子：
5.6
通讯作者：
B. Shane
中科院分区：
文献类型：
--
作者：
S. Milstien;G. Kapatos;R. Levine;B. Shane
蝶呤在碱性溶液中的催化还原和随后的空气氧化产生一系列所谓的二聚蝶啶。二聚体A和B的结构解析表明，预期的双蝶呤衍生物在嘧啶部分的环收缩下更严重地降解，形成咪唑并（4，5-B）吡嗪衍生物。基于质谱研究和与鲁马嗪二聚化的类比，提出了二聚体A（19）、二聚体B（20）和二聚体D（3）的新结构。
Catalytic reduction of pterin in alkaline solution and subsequent air oxidation produces a series of so-called dimeric pteridines. Structure elucidations of dimer A and B revealed that the expected dipterinyl derivatives are degraded more severely under ring contraction of the pyrimidine moiety to form imidazo(4,5-b)pyrazine derivatives. New structures are proposed for dimer A (19), dimer B (20) and dimer D (3) based upon mass spectral studies and analogies to lumazine dimerisations.