Radiation Damage in Biomolecular Systems
Radiation Damage in Biomolecular Systems
复制标题
生物分子系统的辐射损伤
DOI：
10.1007/978-94-007-2564-5_23
复制
发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Prise K
中科院分区：
文献类型：
--
作者：
Prise K
新的辐射输送技术方法的出现推动了我们对亚细胞、细胞、组织和全身各级辐射反应的理解迅速发展。电离辐射微束允许以高空间精度递送精确剂量的辐射。它们通过最近在成像、软件和射束输送方面的进展而发展，用于探测辐射反应的空间、时间和低剂量方面的一系列实验研究。全世界已经开发出一系列微束，其中包括能够传递带电粒子、X射线和电子的微束。其发展的最初理由是作为一种精确的手段来测量单一辐射轨迹的影响。然而，在亚细胞靶点用微束靶向辐射的能力已被用于解决与细胞内的辐射敏感位点相关的基本问题。进一步的发展包括使用微束瞄准更复杂的3-D系统，其中利用微束在空间和时间传递方面的独特特性的可能性将产生重大影响。
Rapid advances in our understanding of radiation responses, at the subcellular, cellular, tissue and whole body levels have been driven by the advent of new technological approaches for radiation delivery. Ionising radiation microbeams allow precise doses of radiation to be delivered with high spatial accuracy. They have evolved through recent advances in imaging, software and beam delivery to be used in a range of experimental studies probing spatial, temporal and low dose aspects of radiation response. A range of microbeams have been developed worldwide which include ones capable of delivering charged particles, X-rays and electrons. The original rational for their development was as a precise means of measuring the effects of single radiation tracks. However, the ability to target radiation with microbeams at subcellular targets has been used to address fundamental questions related to radiosensitive sites within cells. Further developments include using microbeams to target more complex 3-D systems where the possibilities of utilizing the unique characteristics of microbeams in terms of their spatial and temporal delivery will make a major impact.