Homocysteine in tear fluid of patients with pseudoexfoliation glaucoma
Homocysteine in tear fluid of patients with pseudoexfoliation glaucoma
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DOI：
10.1097/ijg.0b013e31802d6942
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发表时间：
2007-03-01
影响因子：
2
通讯作者：
Juenemann, Anselm G.
中科院分区：
文献类型：
--
作者：
Roedl, Johannes B.;Bleich, Stefan;Juenemann, Anselm G.
目的：探讨假性剥脱性青光眼(PEXG)患者泪液和血浆中同型半胱氨酸(Hcy)水平及其与维生素B水平的关系。结果：PEXG患者和对照组泪液中均检测到Hcy。经t检验，PEXG患者泪液Hcy水平(237+/-133nmol/L vs.128.54nmoL/L；P<；0.001)和血浆Hcy水平(14.51+/-4.43mMol/L vs.10.22+/-2.77mMol/L；P<；0.001)均显著高于对照组。泪液同型半胱氨酸与血浆同型半胱氨酸水平呈显著正相关(r=0.438，P=0.015)，与血清B-12水平呈显著负相关(r=-0.424，P=0.019)。需要进一步的研究来评估同型半胱氨酸在与PEXG相关的眼表和全身疾病中可能的临床作用。
Purpose: To evaluate homocysteine (Hcy) concentrations in tear fluid and plasma and their association with B-vitamin levels in patients with pseudoexfoliation glaucoma (PEXG).Patients and Methods: Reflex tear and blood samples were obtained in 30 patients with PEXG and 30 controls. Hcy levels were determined by high-performance liquid chromatography.Results: Hcy was detected in all tear fluid samples of patients with PEXG and controls. Statistical analysis with t tests showed that patients with PEXG had significantly higher Hcy levels both in tear fluid (237 +/- 133 nmol/L vs. 128 54 nmol/L; P < 0.001) and in plasma (14.51 +/- 4.43 mu mol/L vs. 10.22 +/- 2.77 mu mol/L; P < 0.001) than control subjects. Hcy in tear fluid correlated significantly with Hcy in plasma (r = 0.438, P = 0.015) and with serum B-12 levels (r = - 0.424, P = 0.019) in patients with PEXG, but not in controls.Conclusions: The study suggests increased Hcy levels in tear fluid and plasma of patients with PEXG. Further investigations are needed to evaluate the possible clinical role of Hcy in ocular surface and systemic disorders associated with PEXG.