Somatic Stem Cells in the Human Endometrium
Somatic Stem Cells in the Human Endometrium
复制标题
DOI：
10.1055/s-0032-1331800
复制
发表时间：
2013-01-01
影响因子：
2.7
通讯作者：
Simon, Carlos
中科院分区：
文献类型：
--
作者：
Cervello, Irene;Mas, Aymara;Simon, Carlos
人子宫内膜体干细胞的存在于20世纪世纪中期被首次提出。这一假说变得更加有力，并在1978年至1989年期间被两位作者修订。然而，直到2004年，科学证据才首次发表。正如我们在这里所描述的，人类子宫内膜的巨大再生能力在过去8年中终于受到质疑，考虑到迄今为止概述的新科学信息，这一时期可以被认为是子宫内膜干细胞生物学最富有成效的时期。我们提供了一个详细的总结的基础上获得的实际科学知识有关（1）存在的体干细胞在小鼠（用标记保留细胞方法检测）和人（通过不同方法分离的细胞）子宫内膜干细胞，（2）骨髓作为子宫内膜体干细胞的假定子宫外来源的参与，（3）这些细胞在子宫内膜异位症和子宫内膜癌等多种病理中的意义和生物学途径;（4）子宫内膜体干细胞在再生医学中的未来，为自体移植和生物工程提供新的策略。
The existence of human endometrial somatic stem cells was proposed in the mid-20th century for the first time. This hypothesis became stronger and was revised by two authors between 1978 and 1989. Nevertheless, it was not until 2004 that scientific evidence was first published. As we describe here, the great regenerative capability of the human endometrium has been finally questioned in the last 8 years, and this period can be considered the most productive in endometrial stem cell biology given the new scientific information recapitulated to date. We provide a detailed summary based on the actual scientific knowledge obtained about (1) the existence of somatic stem cells in murine (detected with label-retaining cell methods) and human (cells isolated by different methods) endometria, (2) the involvement of bone marrow as a putative extrauterine source of endometrial somatic stem cells, (3) the implication and biological pathways of these cells in several pathologies like endometriosis and endometrial cancer, and (4) the future of endometrial somatic stem cells in regenerative medicine to provide new strategies in autologous transplant and bioengineering.