Recombinant parechovirus A3 possibly causes various clinical manifestations, including myalgia; findings in Yamagata, Japan in 2019
Recombinant parechovirus A3 possibly causes various clinical manifestations, including myalgia; findings in Yamagata, Japan in 2019
复制标题
重组副肠孤病毒A3可能引起多种临床表现，包括肌痛；
DOI：
10.1080/23744235.2022.2069857
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发表时间：
2022
影响因子：
5.8
通讯作者：
Ikeda Tatsuya
中科院分区：
文献类型：
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作者：
Mizuta Katsumi;Itagaki Tsutomu;Chikaoka Shuji;Wada Manabu;Ikegami Toru;Sendo Dai;Iseki Chifumi;Shimizu Yukitoshi;Abe Shuichi;Komabayashi Kenichi;Aoki Yoko;Ikeda Tatsuya
背景副肠孤病毒 A3 于 2004 年首次报道，已被认为是儿童轻度和重度感染的病原体。自2008年日本山形县首次报道成人副肠孤病毒A3相关肌痛暴发以来，该病已在日本全国得到认可，但其他国家尚未报告。目的我们分析了2019年山形县发现的19例副肠孤病毒A3感染病例，以进一步阐明该病的流行病学。方法对副肠孤病毒A3分离株进行系统发育分析，分析其临床表现和基因组。结果有两个集群，集群 2019B 在 10 月/11 月左右取代了 2019 A。系统发育分析显示，2019B簇菌株和2012年至2013年间出现的澳大利亚重组菌株在非结构蛋白区域聚集在一个簇中，表明2019B簇菌株这些区域的祖先是澳大利亚重组谱系菌株。这两个集群的菌株引起了儿童的各种感染，包括肌痛。这些发现强烈支持副肠孤病毒A3株引起肌痛和其他儿科感染，无论涉及何种病毒株，包括重组株。结论我们已经报道了多次散发的肌痛病例，这里表明重组株也引起肌痛。我们希望我们的经验将有助于更好地了解这些感染，并可能导致世界上发现更多病例。
BackgroundParechovirus A3 was first reported in 2004 and has been recognized as a causative agent of mild and severe infections in children. Since we first reported an outbreak of adult parechovirus A3-associated myalgia in Yamagata, Japan in 2008, this disease has since been recognized across Japan, but has not yet been reported from other countries.AimWe analysed 19 cases of parechovirus A3 infections identified in Yamagata in 2019 to further clarify the epidemiology of this disease.MethodsWe performed phylogenetic analyses of parechovirus A3 isolates and analysed the clinical manifestations and the genomic clusters.ResultsThere were two clusters, with cluster 2019B replacing 2019 A around October/November. Phylogenetic analysis revealed that 2019B cluster strains and Australian recombinant strains, which appeared between 2012 and 2013, were grouped in one cluster at non-structural protein regions, suggesting that the ancestor to these regions of 2019B cluster strains were Australian recombinant lineage strains. The strains from both clusters caused various infections in children including myalgia. These findings strongly support that parechovirus A3 strains cause myalgia and other paediatric infections irrespective of the virus strains involved, including recombinant strains.ConclusionsWe have reported repeatedly sporadic cases of myalgia and here showed that recombinant strains also cause myalgia. We hope our experiences will help better understand these infections and possibly result in detection of more cases in the world.