An externally head-mounted wireless neural recording device for laboratory animal research and possible human clinical use.
An externally head-mounted wireless neural recording device for laboratory animal research and possible human clinical use.
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一种用于实验动物研究和可能的人类临床用途的外部头戴式无线神经记录设备。
DOI：
10.1109/embc.2013.6610199
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Nurmikko,ArtoV
中科院分区：
文献类型：
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作者：
Yin,Ming;Li,Hao;Bull,Christopher;Borton,DavidA;Aceros,Juan;Larson,Lawrence;Nurmikko,ArtoV
在本文中，我们提出了一种新型的头戴式无线神经记录设备在一个高度紧凑的包装，专门为不受束缚的实验室动物研究和设计用于未来的移动的人类临床使用。该设备，它采取其输入从一个阵列的皮质内微电极阵列（MEA）有97个宽带并行神经记录通道，并集成到两个定制设计的印刷电路板。这些芯片内置多个低功耗定制集成电路，包括前置放大器ASIC、控制器ASIC以及两个SAR ADC、一个3轴加速度计、一个48 MHz时钟源和一个曼彻斯特编码器。另一款超低功耗RF芯片支持OOK发射器，其中心频率可在3GHz至4GHz范围内调谐，与3V LDO一起安装在单独的低损耗电介质板上，输出馈入UWB芯片天线。将IC板互连并包装在聚醚醚酮（PEEK）外壳中，该外壳与动物和人类使用兼容（例如，可灭菌）。整个系统消耗17 mA的1.2Ahr 3.6V Li-SOCl 2 1/2AA电池，可使设备运行2天以上。整个系统包括定制RF接收器电子器件，其被设计为与任何数量的商业（或定制）神经信号处理器直接接口，用于多通道宽带神经记录。实验台测量和在恒河猴的设备在体内测试，以证明无线神经接口的性能。
In this paper we present a new type of head-mounted wireless neural recording device in a highly compact package, dedicated for untethered laboratory animal research and designed for future mobile human clinical use. The device, which takes its input from an array of intracortical microelectrode arrays (MEA) has ninety-seven broadband parallel neural recording channels and was integrated on to two custom designed printed circuit boards. These house several low power, custom integrated circuits, including a preamplifier ASIC, a controller ASIC, plus two SAR ADCs, a 3-axis accelerometer, a 48MHz clock source, and a Manchester encoder. Another ultralow power RF chip supports an OOK transmitter with the center frequency tunable from 3GHz to 4GHz, mounted on a separate low loss dielectric board together with a 3V LDO, with output fed to a UWB chip antenna. The IC boards were interconnected and packaged in a polyether ether ketone (PEEK) enclosure which is compatible with both animal and human use (e.g. sterilizable). The entire system consumes 17mA from a 1.2Ahr 3.6V Li-SOCl2 1/2AA battery, which operates the device for more than 2 days. The overall system includes a custom RF receiver electronics which are designed to directly interface with any number of commercial (or custom) neural signal processors for multi-channel broadband neural recording. Bench-top measurements and in vivo testing of the device in rhesus macaques are presented to demonstrate the performance of the wireless neural interface.