Regulation of brown fat by AMP-activated protein kinase.
Regulation of brown fat by AMP-activated protein kinase.
复制标题
DOI：
10.1016/j.molmed.2015.07.003
复制
发表时间：
2015-09
影响因子：
13.6
通讯作者：
Andrea D. van Dam;S. Kooijman;M. Schilperoort;P. Rensen;M. Boon
中科院分区：
文献类型：
--
作者：
Andrea D. van Dam;S. Kooijman;M. Schilperoort;P. Rensen;M. Boon
需要新的策略来减少肥胖的流行。一种有前景的策略是通过大脑或直接激活棕色脂肪组织（BAT），通过将脂肪酸（FA）燃烧成热量来增加能量消耗。酶复合物 AMP 激活蛋白激酶 (AMPK) 在能量代谢中发挥着至关重要的作用，在大脑和 BAT 中高度表达，调节生热作用。一般来说，通过抑制大脑中的 AMPK 活性（导致 BAT 的交感神经流出增强）或通过激活 BAT 中的 AMPK 来增加 BAT 活动和能量消耗。因此，靶向 AMPK 可能具有治疗肥胖及相关疾病的潜力。
Novel strategies are needed to reduce the obesity epidemic. One promising strategy is activation of brown adipose tissue (BAT), either via the brain or directly, which increases energy expenditure by combustion of fatty acids (FAs) into heat. The enzyme complex AMP-activated protein kinase (AMPK) is crucially involved in energy metabolism and is highly expressed in both brain and BAT, regulating thermogenesis. As a general rule, BAT activity and energy expenditure are increased either by suppression of AMPK activity in the brain, resulting in enhanced sympathetic outflow towards BAT, or by activation of AMPK in BAT. Targeting AMPK may thus hold therapeutic potential for the treatment of obesity and related disorders.