Intracytoplasmic sperm injection increases embryo fragmentation without affecting clinical outcome.
Intracytoplasmic sperm injection increases embryo fragmentation without affecting clinical outcome.
复制标题
胞浆内单精子注射会增加胚胎破碎，但不会影响临床结果。
DOI：
10.1023/a:1009439800398
复制
发表时间：
2000
影响因子：
3.1
通讯作者：
Segars,JH
中科院分区：
文献类型：
--
作者：
Frattarelli,JL;Leondires,MP;Miller,BT;Segars,JH
目的：比较常规体外受精（IVF）与胞浆内单精子注射（ICSI）对胚胎破碎和着床率的影响。方法：对253例不孕症患者（ICSI 71例，IVF 182例）进行年龄、精液分析、移植胚胎数、胚胎破碎、着床、妊娠率等方面的比较。在整个研究期间，胚胎碎裂由同一实验室的一名观察员确定。结果：IVF（2.2±0.84）与ICSI（2.5±0.77）的平均胚胎分级差异有统计学意义（P = 0.01）。此外，与ICSI组相比，IVF患者有更多的非碎片化（I级）胚胎，P < 0.01。结论：这些数据表明，无论精液参数如何，ICSI可能会增加胚胎碎片，产生更少的非碎片级胚胎，同时保持与常规IVF相似的着床率和妊娠率。
Purpose:To examine the effect of intracytoplasmic sperminjection (ICSI) on embryo fragmentation and implantationrates in those embryos chosen for transfer compared toconventional in vitro fertilization (IVF).Methods:We compared 253 infertility patients (71 ICSI and182 IVF) with respect to age, semen analysis, number ofembryos transferred, embryo fragmentation, implantationrate, and pregnancy rate. Embryo fragmentation wasdetermined by one observer at the same laboratory over the entirestudy period.Results:A statistically significant difference was observedin mean embryo grade between IVF (2.2 ± 0.84) and ICSI(2.5 ± 0.77), P = 0.01. Additionally, the IVF patients hadsignificantly more nonfragmented (grade I) embryoscompared to the ICSI group, P < 0.01.Conclusions:These data suggest that ICSI, irrespective ofsemen parameters, may increase embryo fragmentation andproduce fewer nonfragmented grade I embryos while maintaining implantation and pregnancy rates similar toconventional IVF.