Expedient Synthesis of Biologically Potent Aryloxycoumarins and (Aryloxyimino)ethylcoumarins via Copper(II)-Promoted Chan–Lam Coupling Reaction
Expedient Synthesis of Biologically Potent Aryloxycoumarins and (Aryloxyimino)ethylcoumarins via Copper(II)-Promoted Chan–Lam Coupling Reaction
复制标题
DOI：
10.1080/00397911.2011.594544
复制
发表时间：
2013-01
影响因子：
2.1
通讯作者：
Arunima Medda;G. Pal;Raghunath Singha;Tabassum Hossain;A. Saha;Asish R. Das
中科院分区：
文献类型：
--
作者：
Arunima Medda;G. Pal;Raghunath Singha;Tabassum Hossain;A. Saha;Asish R. Das
摘要介绍了一种简便有效的芳氧香豆素和芳氧亚氨基乙基香豆素的合成方法。所开发的合成路线涉及在催化体系Cu（OAM）2/Et 3 N存在下，由现成的羟基香豆素和（羟亚氨基）乙基香豆素衍生物进行Cu促进的C-O和N-O偶联反应。在此条件下，一系列的芳基硼酸已成功地反应，以相当好的产率得到偶联产物。图形摘要
Abstract A convenient protocol for the efficient synthesis of aryloxycoumarins and (aryloxyimino)ethylcoumarins is described. The synthetic route developed involves the Cu-promoted C-O and N-O coupling reactions from readily available hydroxycoumarin and (hydroxyimino)ethylcoumarin derivatives in the presence of the catalytic system Cu(OAc)2/Et3N. By applying this condition, a series of arylboronic acids have been successfully reacted to afford the coupled products in fair to good yields. GRAPHICAL ABSTRACT