Trajectory estimation in schizophrenia.
Trajectory estimation in schizophrenia.
复制标题
精神分裂症的轨迹估计。
DOI：
10.1016/s0920-9964(99)00166-8
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发表时间：
2000
影响因子：
4.5
通讯作者：
Park,S
中科院分区：
文献类型：
--
作者：
Hooker,C;Park,S
我们进行了两个实验来研究精神分裂症患者在时间和空间上保持内部表征的能力。据推测，精神分裂症患者通过背外侧前额叶皮层（DLPFC）介导的内部表征指导行为的能力受损[e.g. Goldman-Rakic， P.S, 1996]。背外侧前额皮质的功能性包裹化与精神分裂症的异质性。见：《精神病理学：一门新科学的进化》，马蒂斯，S.，列维，D.L.（编）。剑桥大学出版社，剑桥]。在实验1中，受试者观察一个目标，该目标在其轨迹的一部分中穿过不透明的墙。这项任务是通过预测目标何时会再次出现在墙的另一边来准确评估目标的速度。在实验2中，受试者被要求估计一个既定目标路径被另一个物体部分遮挡时的空间轨迹。精神分裂症患者在估计运动目标的速度和估计空间轨迹方面受损，但在控制任务中没有表现出缺陷。这些结果表明，精神分裂症患者可能无法准确地保持一个目标的内部表征随时间和空间的变化。这种缺陷可能会对目标导向的行为产生有害的后果。
Two experiments were conducted to investigate the ability of schizophrenia patients to maintain internal representation over time and space. It has been hypothesized that the ability to guide behavior by internal representation, mediated by the dorsolateral prefrontal cortex (DLPFC), is impaired in schizophrenia [e.g. Goldman-Rakic, P.S., 1996. The functional parcellation of dorsolateral prefrontal cortex and the heterogeneous facets of schizophrenia. In: Matthysse, S., Levy, D.L. (Eds.), Psychopathology: Evolution of a New Science. Cambridge University Press, Cambridge]. In Experiment 1, subjects observed a target, which traveled behind an opaque wall during a part of its trajectory. The task was to accurately assess the speed of the target by predicting when the target would re-emerge on the other side of the wall. In Experiment 2, subjects were asked to estimate the spatial trajectory of an established target path when it was partially occluded from view by another object. Schizophrenia patients were impaired in estimating the speed of a moving target and in estimating the spatial trajectory, without showing deficits in the control tasks. These results suggest that schizophrenia patients may not be able to accurately maintain the internal representation of a target over time and space. Such deficits may have deleterious consequences in goal-directed behavior.