Contrasting effects of vasopressin on baroreflex inhibition of lumbar sympathetic nerve activity.
Contrasting effects of vasopressin on baroreflex inhibition of lumbar sympathetic nerve activity.
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加压素对腰交感神经活动的压力感受反射抑制的对比作用。
DOI：
10.1152/ajpheart.1985.249.5.h922
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Schmid,PG
中科院分区：
文献类型：
--
作者：
Sharabi,FM;Guo,GB;Abboud,FM;Thames,MD;Schmid,PG
对比了静脉注射苯肾上腺素和加压素时压力感受器反射对大鼠和兔腰交感神经活动(LSNA)的抑制作用。在兔中，加压素引起的动脉压升高较小，而对LSNA的抑制作用比苯肾上腺素更大。然而，在Spraogue-Dawley大鼠中，血管加压素和苯肾上腺素都导致了动脉压的增加和LSNA的反射减少。LSNA的抑制是通过两种动物的动脉压力感受器介导的，因为它被去窦弓神经取消。在大鼠中，高水平的内源性加压素可能阻止了注射外源性加压素促进压力反射的可能性，因为加压素也不能促进Brattleboro大鼠的反射，因为Brattleboro大鼠缺乏循环中的加压素。此外，SpragueDawley大鼠对外源性加压素有反应，因为注射更大剂量的加压素导致尿液渗透压显著增加以及动脉压进行性增加。结果表明，静脉注射加压素6min，对兔动脉压力感受器介导的LSNA反射抑制有促进作用，但对大鼠无明显作用。给大鼠注射加压素长达45分钟也不能促进压力感受器反射，强调了与兔子的区别。在兔子身上，这种易化似乎涉及到一种中枢机制。
Baroreflex inhibition of lumbar sympathetic nerve activity (LSNA) during intravenous infusions of phenylephrine and vasopressin is contrasted in rats and rabbits. In rabbits, vasopressin caused smaller increases in arterial pressure and greater inhibition of LSNA than phenylephrine. In Sprague-Dawley rats, however, both vasopressin and phenylephrine caused equivalent increases in arterial pressure and reflex reductions in LSNA. The inhibition of LSNA was mediated through the arterial baroreceptors in both species because it was abolished by sinoaortic denervation. In rats, the possibility that a high level of endogenous vasopressin may have prevented the demonstration of a facilitated baroreflex with the infusion of exogenous vasopressin is unlikely since vasopressin also did not facilitate the reflex in Brattleboro rats, which lack circulating vasopressin. Further, Sprague-Dawley rats were responsive to exogenous vasopressin since infusion of increasing doses of vasopressin caused significant increases in urinary osmolality as well as progressive increments in arterial pressure. The results indicate that intravenous vasopressin given for a period of 6 min facilitates the reflex inhibition of LSNA mediated through arterial baroreceptors in rabbits, but not in rats. Vasopressin given for a period of up to 45 min to rats also fails to facilitate baroreflexes, emphasizing the difference from rabbits. In rabbits, this facilitation appears to involve a central mechanism.