Copper-Catalyzed Enantioselective 1,6-Boration of para-Quinone Methides and Efficient Transformation of gem-Diarylmethine Boronates to Triarylmethanes
Copper-Catalyzed Enantioselective 1,6-Boration of para-Quinone Methides and Efficient Transformation of gem-Diarylmethine Boronates to Triarylmethanes
复制标题
铜催化对醌甲基化物的对映选择性 1,6-硼化反应以及宝石二芳基次甲基硼酸酯向三芳基甲烷的高效转化
DOI：
10.1002/anie.201505926
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发表时间：
2015-10-05
影响因子：
16.6
通讯作者：
Liao, Jian
中科院分区：
文献类型：
--
作者：
Lou, Yazhou;Cao, Peng;Liao, Jian
首次报道了铜催化的二硼频哪醇酯与对苯醌甲基化物的1，6-共轭加成反应。该反应以优异的产率和良好至优异的对映选择性进行，并提供了一种有吸引力的方法来构建光学活性的偕二芳基甲基硼酸酯。此外，衍生的三氟硼酸钾转化为三芳基甲烷具有高度的对映体特异性实现。
Presented is the first enantioselective copper-catalyzed 1,6-conjugate addition of bis(pinacolato) diboron to para-quinone methides. The reaction proceeds with excellent yields and good to excellent enantioselectivities, and provides an attractive approach to the construction of optically active gem-diarylmehtine boronic esters. Additionally, the subsequent conversion of the derived potassium trifluoroborates into triarylmethanes with highly enantiospecificity was realized.