Efficient and Ecofriendly Protocol for Tetrahydropyranylation/Depyranylation of Alcohols in the Presence of Tin(II) Chloride Dihydrate
Efficient and Ecofriendly Protocol for Tetrahydropyranylation/Depyranylation of Alcohols in the Presence of Tin(II) Chloride Dihydrate
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DOI：
10.1080/00397910601055123
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发表时间：
2007-03
影响因子：
2.1
通讯作者：
Dipankoj Gogoi;Nabajyoti Baruah;G. Bez
中科院分区：
文献类型：
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作者：
Dipankoj Gogoi;Nabajyoti Baruah;G. Bez
摘要报道了一种温和、高效、无溶剂的四氢吡喃化反应。通过短硅胶垫简单过滤反应混合物，以优异的产率获得纯产物。脱吡喃化也可以通过在类似的反应条件下加入甲醇来实现。
Abstract A mild, efficient, and solvent‐free protocol for tetrahydropyranylation of alcohols in the presence of a catalytic amount of SnCl2 · 2H2O is reported. Simple filtration of the reaction mixture through a short silica‐gel pad gives the pure products in excellent yields. Depyranylation can also be achieved by adding methanol under similar reaction conditions.