Multilayered microfilter using a nanoporous PES membrane and applicable as the dialyzer of a wearable artificial kidney
Multilayered microfilter using a nanoporous PES membrane and applicable as the dialyzer of a wearable artificial kidney
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DOI：
10.1088/0960-1317/19/6/065031
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发表时间：
2009-06-01
影响因子：
2.3
通讯作者：
Miki, Norihisa
中科院分区：
文献类型：
--
作者：
Gu, Ye;Miki, Norihisa
我们提出了一种多层微过滤器，用作可穿戴人工肾的透析器，从血液中分离尿素、尿酸和肌酐等代谢废物。微过滤器装置通过交替结合由湿蚀刻制成的Ti腔室层和由湿相转化法制成的聚醚砜（PES）半渗透聚合物膜来组装。夹在每两个腔室层之间的PES膜充当大于1.7 nm的分子的屏障。多层微过滤器的几何优化相对于我们的理论方程和实验结果，以获得肾脏的竞争力的性能。我们的装置的每个扩散单元的尺寸仅为24 × 24 × 0.4 mm（3），实验证明，在输入压力仅为10 kPa（人肾动脉中的静水压力）的情况下，能够允许高达1 ml/min（-1）的流速，同时具有18 μ g/min（-1）的尿素去除率。
We present a multilayered microfilter for use as a dialyzer of a wearable artificial kidney separating metabolic wastes such as urea, uric acid and creatinine from blood. The microfilter device is assembled by alternately bonding chamber layers made of Ti by wet etching and semipermeable polymeric membranes made of polyethersulfone (PES) by the wet phase inversion method. The PES membranes sandwiched between each two chamber layers act as barriers to molecules larger than 1.7 nm. The multilayered microfilter was geometrically optimized with respect to our theoretical equations and experimental results in order to obtain kidney-competitive performance. Each diffusing unit of our device, which is only 24 x 24 x 0.4 mm(3) in size, was proved experimentally to be capable of allowing a flow rate of up to 1 ml min(-1) under an input pressure of only 10 kPa, which is the hydrostatic pressure in human renal arteries, while having a urea removal rate of 18 mu g min(-1).