Tissue-resident cytotoxic innate lymphoid cells in tumor immunosurveillance.
Tissue-resident cytotoxic innate lymphoid cells in tumor immunosurveillance.
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DOI：
10.1016/j.smim.2019.03.001
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发表时间：
2019-02
影响因子：
7.8
通讯作者：
Efstathios G. Stamatiades;Ming O. Li
中科院分区：
文献类型：
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作者：
Efstathios G. Stamatiades;Ming O. Li
天然淋巴细胞在维持组织稳态和炎症过程中的动态平衡中起重要作用。与生俱来的淋巴细胞群体是令人难以置信的多样性和异质性，随着新的亚群的不断鉴定，包括来自不同于自然杀伤细胞的前体细胞的固有淋巴样细胞。虽然通常被认为是T辅助淋巴细胞，但在许多组织中都可以识别出具有细胞毒活性的固有淋巴样细胞。来源于先天淋巴样细胞和/或自然杀伤细胞系的组织驻留细胞毒性先天淋巴细胞在感知恶性转化和启动抗肿瘤免疫方面具有很好的地位。本文就天然淋巴细胞生物学及其在肿瘤免疫监测中的作用作一综述。
Innate lymphocytes play an important role in maintaining tissue homeostasis at steady state and during inflammation. The population of innate lymphocytes is incredibly diverse and heterogeneous with the successive identification of new subsets including innate lymphoid cells that arise from progenitors distinct from those of natural killer cells. Although generally considered as T helper-like lymphocytes, innate lymphoid cells with cytotoxic potential can be identified in many tissues. The tissue-resident cytotoxic innate lymphocytes derived from innate lymphoid cell and/or natural killer cell lineages are well positioned in sensing malignant transformation and initiating antitumor immunity. This review provides an overview of innate lymphocyte biology and discuss their roles in tumor immunosurveillance.