Phytochemicals from the aerial parts of Ligularia thomsonii and their radical scavenging activity
Phytochemicals from the aerial parts of Ligularia thomsonii and their radical scavenging activity
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DOI：
10.1016/j.phytol.2013.09.002
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发表时间：
2014-02
影响因子：
1.7
通讯作者：
S. H. Hussain;A. Latif;R. Cox;T. J. Simpson;Mumtaz Ali;M. Arfan;G. Uddin
中科院分区：
文献类型：
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作者：
S. H. Hussain;A. Latif;R. Cox;T. J. Simpson;Mumtaz Ali;M. Arfan;G. Uddin
通过对汤松柳属植物地上部分的植物化学研究，分离到3个新的苯丙类糖苷：ligularoside I(1)、ligularoside II(2)和ligularoside III(3)以及9个已知化合物；肉桂酸(4)，3-苯基丙酸(5),3,4,5-三羟基苯甲酸(6)，4-羟基苯甲酸(7)，对香豆酸(8)，咖啡酸(9),3,4-二羟基苯甲酸（10），山奈酚3- o -β-d-葡萄糖苷（11）和3,5-二- o -咖啡酰奎宁酸（12），迄今未报道。thomsonii。通过光谱分析和化学转化鉴定了它们的化学结构。采用1,1-二苯基-2-苦味酰肼（DPPH）自由基清除法检测所有化合物的抗氧化活性。其中化合物9、10和12对DPPH自由基具有较强的抗氧化活性，ic50分别为19.6、23.3和8.9 μm。
Phytochemical investigation of the aerial parts ofLigularia thomsoniihas led to the isolation of three new phenylpropanoid glucosides ligularoside I (1), ligularoside II (2) and ligularoside III (3) along with nine known compounds; cinnamic acid (4), 3-phenylpropanoic acid (5), 3,4,5-trihydroxybenzoic acid (6), 4-hydroxybenzoic acid (7),p-coumaric acid (8), caffeic acid (9), 3,4-dihydroxybenzoic acid (10), kaempferol 3-O-β-d-glucopyranoside (11) and 3,5-di-O-caffeoylquinic acid (12), hitherto unreported fromL. thomsonii. Their chemical structures were elucidated by spectroscopic analysis and chemical transformation. All these compounds were tested for antioxidant activity using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging assay. Among them, compounds 9, 10 and 12 showed significant antioxidant activity against DPPH radicals with IC50of 19.6, 23.3 and 8.9 μm, respectively.