Cortical Correlates of the Auditory Frequency-Following and Onset Responses: EEG and fMRI Evidence
Cortical Correlates of the Auditory Frequency-Following and Onset Responses: EEG and fMRI Evidence
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DOI：
10.1523/jneurosci.1265-16.2016
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发表时间：
2017-01-25
影响因子：
5.3
通讯作者：
Zatorre, Robert J.
中科院分区：
文献类型：
--
作者：
Coffey, Emily B. J.;Musacchia, Gabriella;Zatorre, Robert J.
频率跟随响应（FFR）是大脑周期性声音编码的量度。人类听觉神经系统与听觉认知和听觉功能障碍有着密切的联系，因此对听觉神经系统的研究越来越重要。尽管FFR被广泛解释为源自脑干核，但是最近使用MEG的研究表明，在基频处也存在来自听觉皮层的右侧化贡献（Coffey等人，2016年b）。我们目前工作的目标是使用完全不同的神经成像模式验证和更好地定位该结果，并记录FFR、发作反应和皮质活动之间的关系。使用EEG，fMRI和弥散加权成像的组合，我们发现，在右听觉皮层的活动与FFR-基频（f（0））强度的个体差异有关，这一发现被复制了两个独立的刺激集，有和没有声能的基本频率。我们证明了在右侧的FFR-f（0）敏感反应与左侧听觉皮层的一个区域之间存在分离，该区域对声音起始的初始反应时间的个体差异敏感。与时间及其偏侧化的关系得到了底层白色物质微观结构中的相似性的支持，暗示了涉及神经传导效率的机制。这些数据证实了血流储备分数具有皮质贡献，并提出了通过将早期声音表征与更高级别声音处理和认知功能的测量相联系来推进听觉神经科学的方法。
The frequency-following response (FFR) is a measure of the brain's periodic sound encoding. It is of increasing importance for studying the human auditory nervous system due to numerous associations with auditory cognition and dysfunction. Although the FFR is widely interpreted as originating from brainstem nuclei, a recent study using MEG suggested that there is also a right-lateralized contribution from the auditory cortex at the fundamental frequency (Coffey et al., 2016b). Our objectives in the present work were to validate and better localize this result using a completely different neuroimaging modality and to document the relationships between the FFR, the onset response, and cortical activity. Using a combination of EEG, fMRI, and diffusion-weighted imaging, we show that activity in the right auditory cortex is related to individual differences in FFR-fundamental frequency (f(0)) strength, a finding that was replicated with two independent stimulus sets, with and without acoustic energy at the fundamental frequency. We demonstrate a dissociation between this FFR-f(0)-sensitive response in the right and an area in left auditory cortex that is sensitive to individual differences in the timing of initial response to sound onset. Relationships to timing and their lateralization are supported by parallels in the microstructure of the underlying white matter, implicating a mechanism involving neural conduction efficiency. These data confirm that the FFR has a cortical contribution and suggest ways in which auditory neuroscience may be advanced by connecting early sound representation to measures of higher-level sound processing and cognitive function.