Comparison of independent double readings and computer-aided diagnosis (CAD) for the diagnosis of breast calcifications
Comparison of independent double readings and computer-aided diagnosis (CAD) for the diagnosis of breast calcifications
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DOI：
10.1016/j.acra.2005.09.086
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发表时间：
2006-01-01
影响因子：
4.8
通讯作者：
Schmidt, RA
中科院分区：
文献类型：
--
作者：
Jiang, YL;Metz, CE;Schmidt, RA
理论基础和目标。本研究的目的是比较放射科医生的独立双倍读数和计算机辅助诊断(CAD)在乳房摄影钙化的诊断解释中的作用。10位放射科医生独立解读了104张包含簇状微钙化的乳房X光照片。其中46例是恶性的，58例是良性的。放射科医生使用平衡研究设计，在有和没有电脑辅助的情况下阅读图像。根据观察者的活检建议计算灵敏度和特异度，并根据他们的诊断置信度计算受试者的工作特征(ROC)曲线。通过使用三个不同的客观规则和模拟-最佳双重阅读的附加规则，假定为解决两个放射科医生的不同独立诊断而进行的会诊总是产生正确的临床建议，在特定情况下得出非辅助双重阅读的敏感度和特异值。根据文献资料，得到无辅助二次读数的ROC曲线。在无计算机辅助的情况下，单次读数的敏感性为74%，特异性为32%，而CAD读数的敏感性为87%，特异性为42%，并出现较高的ROC曲线(P
Rationale and Objectives. The aim of the study is to compare independent double readings by radiologists and computer-aided diagnosis (CAD) in diagnostic interpretation of mammographic calcifications.Materials and Methods. Ten radiologists independently interpreted 104 mammograms containing clustered microcalcifications. Forty-six of these were malignant and 58 were benign at biopsy. Radiologists read the images with and without a computer aid by using a counterbalanced study design. Sensitivity and specificity were calculated from observer biopsy recommendations, and receiver operating characteristic (ROC) curves were computed from their diagnostic confidence ratings. Unaided double-reading sensitivity and specificity values were derived post hoc by using three different objective rules and an additional rule of simulated-optimal double reading that assumed that consultations for resolving two radiologists' different independent diagnoses always produce the correct clinical recommendation. ROC curves of unaided double readings were obtained according to the literature.Results. Single reading without computer aid yielded 74% sensitivity and 32% specificity, whereas CAD reading yielded 87% sensitivity and 42% specificity and appeared on a higher ROC curve (P