The amino-terminal phosphorylation sites of C-MYC are frequently mutated in Burkitt's lymphoma lines but not in mouse plasmacytomas and rat immunocytomas.
The amino-terminal phosphorylation sites of C-MYC are frequently mutated in Burkitt's lymphoma lines but not in mouse plasmacytomas and rat immunocytomas.
复制标题
C-MYC 的氨基末端磷酸化位点在伯基特淋巴瘤系中经常发生突变，但在小鼠浆细胞瘤和大鼠免疫细胞瘤中则没有。
DOI：
10.1016/0959-8049(95)00449-1
复制
发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Klein,G
中科院分区：
文献类型：
--
作者：
Axelson,H;Henriksson,M;Wang,Y;Magnusson,KP;Klein,G
We sequenced the region encoding the amino-terminal phosphorylation sites of C-MYC in the Ig/MYC translocation-carrying Burkitt lymphomas (BL), mouse plasmacytomas (MPC) and rat immunocytomas (RIC). Mutations affecting the Thr-58 codon or the immediate flanking region were found in seven of the 10 in vitro propagated BL lines. No mutations were found in any of the eight BL biopsies analysed. Germ-line sequences were also found in six in vivo and five in vitro passaged MPCs and in four in vivo transplanted RICs. These findings indicate that mutations in this region do not represent a general phenomena in Ig/MYC translocationcarrying tumours, but may confer growth advantage on BL cells under continuous in vitro propagation.
